STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AAZ69471.12, 5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one reductase. (232 aa)    
Predicted Functional Partners:
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
 
 
 0.964
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 
 0.946
AAZ70016.1
5-amino-6-(5-phosphoribosylamino) uracil reductase.
     
  0.900
AAZ70534.1
Pyruvate carboxylase subunit A.
   
 
 0.719
AAZ69468.1
Chlorohydrolase family protein.
 
   
 0.689
hisG
ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.662
AAZ69470.1
Conserved hypothetical protein.
  
  
 0.660
prf1
Peptide chain release factor subunit 1 (aeRF-1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
   
   0.658
prf1-2
Peptide chain release factor subunit 1 (aeRF-1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
   
   0.658
AAZ72138.1
Conserved hypothetical protein.
   
   0.658
Your Current Organism:
Methanosarcina barkeri Fusaro
NCBI taxonomy Id: 269797
Other names: M. barkeri str. Fusaro, Methanosarcina barkeri DSM 804, Methanosarcina barkeri str. Fusaro, Methanosarcina barkeri strain Fusaro
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