STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiF-2Thiamin biosynthesis thiocarboxylate synthase. (269 aa)    
Predicted Functional Partners:
thiS-2
Thiamin biosynthesis sulfur carrier protein.
 
 
 0.977
Gmet_1569
Zinc-dependent isopeptidase.
 
 
 0.958
tusA-1
tRNA (5-carboxymethylaminomethyl-2-thio-U34) synthesis sulfur carrier protein.
 
   
 0.928
thiE/thiD
4-amino-5-hydroxymethyl-2-methylpyrimidine- phosphate kinase and thiamin monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.891
Gmet_1570
Sulfite reductase subunit, putative.
 
    0.875
thiG
Carboxythiazole phosphate tautomer synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.797
moaD
Molybdopterin biosynthesis sulfur carrier protein.
  
 
 0.780
metY-3
O-acetyl-L-homoserine sulfhydrylase.
  
    0.757
thiS-1
Thiamin biosynthesis sulfur carrier protein.
  
 
 0.742
trxB
Thioredoxin reductase.
  
  
 0.618
Your Current Organism:
Geobacter metallireducens
NCBI taxonomy Id: 269799
Other names: G. metallireducens GS-15, Geobacter metallireducens GS-15, Geobacter metallireducens str. GS-15, Geobacter metallireducens strain GS-15
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.