STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tfu_0671SMF protein. (394 aa)    
Predicted Functional Partners:
Tfu_0670
Mg chelatase-related protein.
 
 0.968
Tfu_0669
Conserved hypothetical protein; Belongs to the UPF0102 family.
 
    0.895
Tfu_0825
ComEC/Rec2-related protein.
 
  
 0.820
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 0.684
Tfu_2493
Conserved hypothetical protein.
 
 
 0.608
Tfu_1089
Hypothetical protein.
  
  
 0.575
Tfu_0530
Superfamily I DNA and RNA helicases.
 
  
 0.542
Tfu_0667
Signal peptidase I. Serine peptidase. MEROPS family S26A; Belongs to the peptidase S26 family.
 
     0.534
Tfu_0610
Diguanylate cyclase/phosphodiesterase.
   
    0.506
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
 
     0.477
Your Current Organism:
Thermobifida fusca
NCBI taxonomy Id: 269800
Other names: T. fusca YX, Thermobifida fusca YX, Thermobifida fusca str. YX, Thermobifida fusca strain YX
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.