STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
leuAYeast 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (568 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 0.993
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.992
ilvD
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
  
 
 0.988
Tfu_0616
Branched chain amino acid aminotransferase.
  
 0.986
Tfu_0612
Acetolactate synthase, small subunit.
 
 
 0.966
Tfu_2112
Putative aminotransferase.
  
 0.963
Tfu_2674
2-oxoglutarate ferredoxin oxidoreductase, alpha subunit.
  
 
 0.940
Tfu_0947
Putative acetyl/propionyl CoA carboxylase alpha subunit: biotin carboxylase.
  
 
 0.938
Tfu_1228
Putative acyl-CoA carboxylase complex A subunit.
  
 
 0.938
Tfu_2557
Putative acyl-CoA carboxylase, alpha subunit.
  
 
 0.938
Your Current Organism:
Thermobifida fusca
NCBI taxonomy Id: 269800
Other names: T. fusca YX, Thermobifida fusca YX, Thermobifida fusca str. YX, Thermobifida fusca strain YX
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.