node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tfu_0440 | Tfu_0602 | Tfu_0440 | Tfu_0602 | Cystathionine gamma-lyase. | Conserved hypothetical protein. | 0.540 |
Tfu_0440 | Tfu_1050 | Tfu_0440 | Tfu_1050 | Cystathionine gamma-lyase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.754 |
Tfu_0440 | Tfu_1825 | Tfu_0440 | Tfu_1825 | Cystathionine gamma-lyase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.980 |
Tfu_0440 | metK | Tfu_0440 | Tfu_1065 | Cystathionine gamma-lyase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.446 |
Tfu_0602 | Tfu_0440 | Tfu_0602 | Tfu_0440 | Conserved hypothetical protein. | Cystathionine gamma-lyase. | 0.540 |
Tfu_0602 | Tfu_0632 | Tfu_0602 | Tfu_0632 | Conserved hypothetical protein. | Cystathionine gamma-synthase. | 0.540 |
Tfu_0602 | Tfu_1050 | Tfu_0602 | Tfu_1050 | Conserved hypothetical protein. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.888 |
Tfu_0602 | Tfu_1825 | Tfu_0602 | Tfu_1825 | Conserved hypothetical protein. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.831 |
Tfu_0602 | glyA | Tfu_0602 | Tfu_2353 | Conserved hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.490 |
Tfu_0602 | metK | Tfu_0602 | Tfu_1065 | Conserved hypothetical protein. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.783 |
Tfu_0632 | Tfu_0602 | Tfu_0632 | Tfu_0602 | Cystathionine gamma-synthase. | Conserved hypothetical protein. | 0.540 |
Tfu_0632 | Tfu_1050 | Tfu_0632 | Tfu_1050 | Cystathionine gamma-synthase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.754 |
Tfu_0632 | Tfu_1825 | Tfu_0632 | Tfu_1825 | Cystathionine gamma-synthase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.808 |
Tfu_0632 | metK | Tfu_0632 | Tfu_1065 | Cystathionine gamma-synthase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.446 |
Tfu_1050 | Tfu_0440 | Tfu_1050 | Tfu_0440 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Cystathionine gamma-lyase. | 0.754 |
Tfu_1050 | Tfu_0602 | Tfu_1050 | Tfu_0602 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Conserved hypothetical protein. | 0.888 |
Tfu_1050 | Tfu_0632 | Tfu_1050 | Tfu_0632 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Cystathionine gamma-synthase. | 0.754 |
Tfu_1050 | Tfu_1387 | Tfu_1050 | Tfu_1387 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.930 |
Tfu_1050 | Tfu_1825 | Tfu_1050 | Tfu_1825 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.998 |
Tfu_1050 | folD | Tfu_1050 | Tfu_2571 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |