KXA16451.1 protein (Gardnerella vaginalis) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

KXA16451.1

Mevalonate kinase; KEGG: gvg:HMPREF0421_21153 1.7e-119 mvk; putative mevalonate kinase K00869; Psort location: Cytoplasmic, score: 7.50. (387 aa)

Predicted Functional Partners:

KXA16452.1

0.986

KXA16368.1

0.982

KXA16366.1

0.938

KXA16453.1

0.931

KXA16645.1

0.708

KXA17057.1

0.674

KXA16370.1

0.457

KXA16449.1

0.453

RpmB

0.444

KXA17591.1

0.418

Your Current Organism:

Gardnerella vaginalis

NCBI taxonomy Id: 2702
Other names: ATCC 14018, CCUG 3717, CIP 70.74, Corynebacterium vaginale, DSM 4944, G. vaginalis, Haemophilus hemolyticus vaginalis, Haemophilus vaginalis, JCM 11026, LMG 7832, LMG:7832, NCTC 10287, NCTC 10915, strain 594

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KXA16366.1	KXA16368.1	HMPREF3204_00539	HMPREF3204_00541	KEGG: gvh:HMPREF9231_0430 6.1e-193 hydroxymethylglutaryl-CoA synthase K01641; Psort location: Cytoplasmic, score: 7.50.	KEGG: gvh:HMPREF9231_0431 1.6e-208 hydroxymethylglutaryl-CoA reductase, degradative K00054; Psort location: Cytoplasmic, score: 7.50.	0.960
KXA16366.1	KXA16370.1	HMPREF3204_00539	HMPREF3204_00543	KEGG: gvh:HMPREF9231_0430 6.1e-193 hydroxymethylglutaryl-CoA synthase K01641; Psort location: Cytoplasmic, score: 7.50.	KEGG: gvg:HMPREF0421_21107 5.1e-196 atoB; acetyl-CoA acetyltransferase K00626; Psort location: Cytoplasmic, score: 9.97.	0.985
KXA16366.1	KXA16451.1	HMPREF3204_00539	HMPREF3204_00485	KEGG: gvh:HMPREF9231_0430 6.1e-193 hydroxymethylglutaryl-CoA synthase K01641; Psort location: Cytoplasmic, score: 7.50.	Mevalonate kinase; KEGG: gvg:HMPREF0421_21153 1.7e-119 mvk; putative mevalonate kinase K00869; Psort location: Cytoplasmic, score: 7.50.	0.938
KXA16366.1	KXA16452.1	HMPREF3204_00539	HMPREF3204_00486	KEGG: gvh:HMPREF9231_0430 6.1e-193 hydroxymethylglutaryl-CoA synthase K01641; Psort location: Cytoplasmic, score: 7.50.	KEGG: gvh:HMPREF9231_0384 2.5e-132 mvaD; diphosphomevalonate decarboxylase K01597.	0.965
KXA16366.1	KXA16453.1	HMPREF3204_00539	HMPREF3204_00487	KEGG: gvh:HMPREF9231_0430 6.1e-193 hydroxymethylglutaryl-CoA synthase K01641; Psort location: Cytoplasmic, score: 7.50.	KEGG: gvg:HMPREF0421_21151 0. fni; putative isopentenyl-diphosphate delta-isomerase K01823; Psort location: Cytoplasmic, score: 9.97.	0.864
KXA16366.1	KXA17591.1	HMPREF3204_00539	HMPREF3204_00021	KEGG: gvh:HMPREF9231_0430 6.1e-193 hydroxymethylglutaryl-CoA synthase K01641; Psort location: Cytoplasmic, score: 7.50.	Polyprenyl synthetase; KEGG: gvh:HMPREF9231_0947 7.4e-149 polyprenyl synthetase; K13787 geranylgeranyl diphosphate synthase, type I; Psort location: Cytoplasmic, score: 9.97.	0.611
KXA16368.1	KXA16366.1	HMPREF3204_00541	HMPREF3204_00539	KEGG: gvh:HMPREF9231_0431 1.6e-208 hydroxymethylglutaryl-CoA reductase, degradative K00054; Psort location: Cytoplasmic, score: 7.50.	KEGG: gvh:HMPREF9231_0430 6.1e-193 hydroxymethylglutaryl-CoA synthase K01641; Psort location: Cytoplasmic, score: 7.50.	0.960
KXA16368.1	KXA16370.1	HMPREF3204_00541	HMPREF3204_00543	KEGG: gvh:HMPREF9231_0431 1.6e-208 hydroxymethylglutaryl-CoA reductase, degradative K00054; Psort location: Cytoplasmic, score: 7.50.	KEGG: gvg:HMPREF0421_21107 5.1e-196 atoB; acetyl-CoA acetyltransferase K00626; Psort location: Cytoplasmic, score: 9.97.	0.984
KXA16368.1	KXA16451.1	HMPREF3204_00541	HMPREF3204_00485	KEGG: gvh:HMPREF9231_0431 1.6e-208 hydroxymethylglutaryl-CoA reductase, degradative K00054; Psort location: Cytoplasmic, score: 7.50.	Mevalonate kinase; KEGG: gvg:HMPREF0421_21153 1.7e-119 mvk; putative mevalonate kinase K00869; Psort location: Cytoplasmic, score: 7.50.	0.982
KXA16368.1	KXA16452.1	HMPREF3204_00541	HMPREF3204_00486	KEGG: gvh:HMPREF9231_0431 1.6e-208 hydroxymethylglutaryl-CoA reductase, degradative K00054; Psort location: Cytoplasmic, score: 7.50.	KEGG: gvh:HMPREF9231_0384 2.5e-132 mvaD; diphosphomevalonate decarboxylase K01597.	0.863
KXA16368.1	KXA16453.1	HMPREF3204_00541	HMPREF3204_00487	KEGG: gvh:HMPREF9231_0431 1.6e-208 hydroxymethylglutaryl-CoA reductase, degradative K00054; Psort location: Cytoplasmic, score: 7.50.	KEGG: gvg:HMPREF0421_21151 0. fni; putative isopentenyl-diphosphate delta-isomerase K01823; Psort location: Cytoplasmic, score: 9.97.	0.758
KXA16368.1	KXA16645.1	HMPREF3204_00541	HMPREF3204_00433	KEGG: gvh:HMPREF9231_0431 1.6e-208 hydroxymethylglutaryl-CoA reductase, degradative K00054; Psort location: Cytoplasmic, score: 7.50.	KEGG: gvh:HMPREF9231_0965 0. pheT; phenylalanine--tRNA ligase, beta subunit K01890; Psort location: Cytoplasmic, score: 9.97.	0.569
KXA16368.1	KXA17591.1	HMPREF3204_00541	HMPREF3204_00021	KEGG: gvh:HMPREF9231_0431 1.6e-208 hydroxymethylglutaryl-CoA reductase, degradative K00054; Psort location: Cytoplasmic, score: 7.50.	Polyprenyl synthetase; KEGG: gvh:HMPREF9231_0947 7.4e-149 polyprenyl synthetase; K13787 geranylgeranyl diphosphate synthase, type I; Psort location: Cytoplasmic, score: 9.97.	0.650
KXA16370.1	KXA16366.1	HMPREF3204_00543	HMPREF3204_00539	KEGG: gvg:HMPREF0421_21107 5.1e-196 atoB; acetyl-CoA acetyltransferase K00626; Psort location: Cytoplasmic, score: 9.97.	KEGG: gvh:HMPREF9231_0430 6.1e-193 hydroxymethylglutaryl-CoA synthase K01641; Psort location: Cytoplasmic, score: 7.50.	0.985
KXA16370.1	KXA16368.1	HMPREF3204_00543	HMPREF3204_00541	KEGG: gvg:HMPREF0421_21107 5.1e-196 atoB; acetyl-CoA acetyltransferase K00626; Psort location: Cytoplasmic, score: 9.97.	KEGG: gvh:HMPREF9231_0431 1.6e-208 hydroxymethylglutaryl-CoA reductase, degradative K00054; Psort location: Cytoplasmic, score: 7.50.	0.984
KXA16370.1	KXA16451.1	HMPREF3204_00543	HMPREF3204_00485	KEGG: gvg:HMPREF0421_21107 5.1e-196 atoB; acetyl-CoA acetyltransferase K00626; Psort location: Cytoplasmic, score: 9.97.	Mevalonate kinase; KEGG: gvg:HMPREF0421_21153 1.7e-119 mvk; putative mevalonate kinase K00869; Psort location: Cytoplasmic, score: 7.50.	0.457
KXA16370.1	KXA16452.1	HMPREF3204_00543	HMPREF3204_00486	KEGG: gvg:HMPREF0421_21107 5.1e-196 atoB; acetyl-CoA acetyltransferase K00626; Psort location: Cytoplasmic, score: 9.97.	KEGG: gvh:HMPREF9231_0384 2.5e-132 mvaD; diphosphomevalonate decarboxylase K01597.	0.579
KXA16370.1	KXA16453.1	HMPREF3204_00543	HMPREF3204_00487	KEGG: gvg:HMPREF0421_21107 5.1e-196 atoB; acetyl-CoA acetyltransferase K00626; Psort location: Cytoplasmic, score: 9.97.	KEGG: gvg:HMPREF0421_21151 0. fni; putative isopentenyl-diphosphate delta-isomerase K01823; Psort location: Cytoplasmic, score: 9.97.	0.457
KXA16370.1	KXA17057.1	HMPREF3204_00543	HMPREF3204_00205	KEGG: gvg:HMPREF0421_21107 5.1e-196 atoB; acetyl-CoA acetyltransferase K00626; Psort location: Cytoplasmic, score: 9.97.	KEGG: gvh:HMPREF9231_0973 3.1e-276 GMP synthase; K01951 GMP synthase (glutamine-hydrolysing); Psort location: Cytoplasmic, score: 7.50.	0.431
KXA16370.1	KXA17591.1	HMPREF3204_00543	HMPREF3204_00021	KEGG: gvg:HMPREF0421_21107 5.1e-196 atoB; acetyl-CoA acetyltransferase K00626; Psort location: Cytoplasmic, score: 9.97.	Polyprenyl synthetase; KEGG: gvh:HMPREF9231_0947 7.4e-149 polyprenyl synthetase; K13787 geranylgeranyl diphosphate synthase, type I; Psort location: Cytoplasmic, score: 9.97.	0.426

page 1 of 4

Network Stats

number of nodes:

10

number of edges:

16

average node degree:

3.2

avg. local clustering coefficient:

0.919

expected number of edges:

9

PPI enrichment p-value:

0.0286

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042147

Retrograde transport, endosome to Golgi

4 of 87

1.96

1.48

0.0014

GO:0072673

Lamellipodium morphogenesis

2 of 7

2.75

0.85

0.0326

GO:0034498

Early endosome to Golgi transport

2 of 9

2.64

0.8

0.0399

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005158

Insulin receptor binding

3 of 23

2.41

1.62

0.0012

GO:1990460

Leptin receptor binding

2 of 4

2.99

1.18

0.0086

GO:1990459

Transferrin receptor binding

2 of 11

2.55

0.94

0.0222

GO:0034452

Dynactin binding

2 of 12

2.52

0.94

0.0222

GO:0035091

Phosphatidylinositol binding

4 of 270

1.47

0.9

0.0118

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030905

Retromer, tubulation complex

4 of 4

3.29

4.72

4.78e-09

GO:0097422

Tubular endosome

2 of 5

2.9

1.48

0.0025

GO:0031901

Early endosome membrane

4 of 180

1.64

1.4

0.0010

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:11485546

(2001) A large family of endosome-localized proteins related to sorting nexin 1.

4 of 6

3.12

2.53

3.54e-05

PMID:24866125

(2014) Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy.

4 of 9

2.94

2.49

4.01e-05

PMID:24735875

(2014) Going forward with retromer.

4 of 9

2.94

2.49

4.01e-05

PMID:18472259

(2008) Retromer.

4 of 9

2.94

2.49

4.01e-05

PMID:31576058

(2019) Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.

5 of 38

2.41

2.42

3.54e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14014

Retromer, tubulation complex

4 of 5

3.2

4.37

1.92e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

hsa04144

Endocytosis

4 of 241

1.51

1.24

0.0016

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030905

Retromer, tubulation complex

4 of 4

3.29

4.69

5.38e-09

GOCC:0097422

Tubular endosome

2 of 5

2.9

1.39

0.0037

GOCC:0010008

Endosome membrane

4 of 330

1.38

0.91

0.0090

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0446

Lipid-binding

4 of 251

1.5

1.11

0.0036

KW-0967

Endosome

4 of 568

1.14

0.59

0.0431

KW-0653

Protein transport

4 of 617

1.11

0.57

0.0431

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09325

Vps5 C terminal like

4 of 5

3.2

4.53

9.72e-09

PF03700

Sorting nexin, N-terminal domain

2 of 2

3.29

1.6

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015404

Sorting nexin/Vps5-like, C-terminal

4 of 5

3.2

4.26

3.02e-08

IPR001683

Phox homology

4 of 46

2.23

2.41

2.73e-05

IPR036871

PX domain superfamily

4 of 51

2.19

2.38

2.73e-05

IPR027267

AH/BAR domain superfamily

4 of 77

2.01

2.03

9.80e-05

IPR005329

Sorting nexin, N-terminal

2 of 2

3.29

1.55

0.0020

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00312

PhoX homologous domain, present in p47phox and p40phox.

3 of 42

2.15

1.59

0.0011

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