KXA15704.1 protein (Gardnerella vaginalis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

KXA15704.1

Adenylate kinase; KEGG: gvh:HMPREF9231_0258 1.0e-87 adk; adenylate kinase K00939; Psort location: Cytoplasmic, score: 9.97. (181 aa)

Predicted Functional Partners:

KXA15703.1

0.993

KXA16696.1

0.956

Pyk

0.949

KXA15705.1

0.947

KXA15700.1

0.939

RplE

0.937

RpsK

0.937

KXA15702.1

0.935

RplR

0.934

RpsM

0.933

Your Current Organism:

Gardnerella vaginalis

NCBI taxonomy Id: 2702
Other names: ATCC 14018, CCUG 3717, CIP 70.74, Corynebacterium vaginale, DSM 4944, G. vaginalis, Haemophilus hemolyticus vaginalis, Haemophilus vaginalis, JCM 11026, LMG 7832, LMG:7832, NCTC 10287, NCTC 10915, strain 594

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KXA15700.1	KXA15702.1	HMPREF3204_00965	HMPREF3204_00967	Ribosomal protein S5; KEGG: apb:SAR116_2408 1.1e-35 30S ribosomal protein S5 K02988; Psort location: Cytoplasmic, score: 9.97.	Ribosomal protein L15; KEGG: apb:SAR116_2410 9.9e-19 50S ribosomal protein L15 K02876.	0.999
KXA15700.1	KXA15703.1	HMPREF3204_00965	HMPREF3204_00968	Ribosomal protein S5; KEGG: apb:SAR116_2408 1.1e-35 30S ribosomal protein S5 K02988; Psort location: Cytoplasmic, score: 9.97.	KEGG: apb:SAR116_2411 2.0e-82 preprotein translocase subunit SecY K03076; Psort location: CytoplasmicMembrane, score: 10.00.	0.999
KXA15700.1	KXA15704.1	HMPREF3204_00965	HMPREF3204_00969	Ribosomal protein S5; KEGG: apb:SAR116_2408 1.1e-35 30S ribosomal protein S5 K02988; Psort location: Cytoplasmic, score: 9.97.	Adenylate kinase; KEGG: gvh:HMPREF9231_0258 1.0e-87 adk; adenylate kinase K00939; Psort location: Cytoplasmic, score: 9.97.	0.939
KXA15700.1	KXA15705.1	HMPREF3204_00965	HMPREF3204_00970	Ribosomal protein S5; KEGG: apb:SAR116_2408 1.1e-35 30S ribosomal protein S5 K02988; Psort location: Cytoplasmic, score: 9.97.	KEGG: bcz:BCZK0127 9.0e-25 infA; translation initiation factor IF-1 K02518; Psort location: Cytoplasmic, score: 9.97.	0.999
KXA15700.1	Pyk	HMPREF3204_00965	HMPREF3204_00164	Ribosomal protein S5; KEGG: apb:SAR116_2408 1.1e-35 30S ribosomal protein S5 K02988; Psort location: Cytoplasmic, score: 9.97.	Pyruvate kinase; KEGG: gvg:HMPREF0421_20976 5.7e-261 pyk; pyruvate kinase K00873; Psort location: Cytoplasmic, score: 7.50.	0.956
KXA15700.1	RplE	HMPREF3204_00965	HMPREF3204_00961	Ribosomal protein S5; KEGG: apb:SAR116_2408 1.1e-35 30S ribosomal protein S5 K02988; Psort location: Cytoplasmic, score: 9.97.	Ribosomal protein L5; Psort location: Cytoplasmic, score: 7.50.	0.999
KXA15700.1	RplR	HMPREF3204_00965	HMPREF3204_00964	Ribosomal protein S5; KEGG: apb:SAR116_2408 1.1e-35 30S ribosomal protein S5 K02988; Psort location: Cytoplasmic, score: 9.97.	KEGG: apb:SAR116_2407 5.1e-15 50S ribosomal protein L18 K02881; Psort location: Cytoplasmic, score: 9.67.	0.999
KXA15700.1	RpsK	HMPREF3204_00965	HMPREF3204_00973	Ribosomal protein S5; KEGG: apb:SAR116_2408 1.1e-35 30S ribosomal protein S5 K02988; Psort location: Cytoplasmic, score: 9.97.	KEGG: apb:SAR116_2414 5.7e-39 30S ribosomal protein S11 K02948; Psort location: Cytoplasmic, score: 9.67.	0.999
KXA15700.1	RpsM	HMPREF3204_00965	HMPREF3204_00972	Ribosomal protein S5; KEGG: apb:SAR116_2408 1.1e-35 30S ribosomal protein S5 K02988; Psort location: Cytoplasmic, score: 9.97.	KEGG: apb:SAR116_2413 8.9e-34 30S ribosomal protein S13 K02952; Psort location: Cytoplasmic, score: 9.97.	0.999
KXA15702.1	KXA15700.1	HMPREF3204_00967	HMPREF3204_00965	Ribosomal protein L15; KEGG: apb:SAR116_2410 9.9e-19 50S ribosomal protein L15 K02876.	Ribosomal protein S5; KEGG: apb:SAR116_2408 1.1e-35 30S ribosomal protein S5 K02988; Psort location: Cytoplasmic, score: 9.97.	0.999
KXA15702.1	KXA15703.1	HMPREF3204_00967	HMPREF3204_00968	Ribosomal protein L15; KEGG: apb:SAR116_2410 9.9e-19 50S ribosomal protein L15 K02876.	KEGG: apb:SAR116_2411 2.0e-82 preprotein translocase subunit SecY K03076; Psort location: CytoplasmicMembrane, score: 10.00.	0.996
KXA15702.1	KXA15704.1	HMPREF3204_00967	HMPREF3204_00969	Ribosomal protein L15; KEGG: apb:SAR116_2410 9.9e-19 50S ribosomal protein L15 K02876.	Adenylate kinase; KEGG: gvh:HMPREF9231_0258 1.0e-87 adk; adenylate kinase K00939; Psort location: Cytoplasmic, score: 9.97.	0.935
KXA15702.1	KXA15705.1	HMPREF3204_00967	HMPREF3204_00970	Ribosomal protein L15; KEGG: apb:SAR116_2410 9.9e-19 50S ribosomal protein L15 K02876.	KEGG: bcz:BCZK0127 9.0e-25 infA; translation initiation factor IF-1 K02518; Psort location: Cytoplasmic, score: 9.97.	0.999
KXA15702.1	Pyk	HMPREF3204_00967	HMPREF3204_00164	Ribosomal protein L15; KEGG: apb:SAR116_2410 9.9e-19 50S ribosomal protein L15 K02876.	Pyruvate kinase; KEGG: gvg:HMPREF0421_20976 5.7e-261 pyk; pyruvate kinase K00873; Psort location: Cytoplasmic, score: 7.50.	0.959
KXA15702.1	RplE	HMPREF3204_00967	HMPREF3204_00961	Ribosomal protein L15; KEGG: apb:SAR116_2410 9.9e-19 50S ribosomal protein L15 K02876.	Ribosomal protein L5; Psort location: Cytoplasmic, score: 7.50.	0.999
KXA15702.1	RplR	HMPREF3204_00967	HMPREF3204_00964	Ribosomal protein L15; KEGG: apb:SAR116_2410 9.9e-19 50S ribosomal protein L15 K02876.	KEGG: apb:SAR116_2407 5.1e-15 50S ribosomal protein L18 K02881; Psort location: Cytoplasmic, score: 9.67.	0.999
KXA15702.1	RpsK	HMPREF3204_00967	HMPREF3204_00973	Ribosomal protein L15; KEGG: apb:SAR116_2410 9.9e-19 50S ribosomal protein L15 K02876.	KEGG: apb:SAR116_2414 5.7e-39 30S ribosomal protein S11 K02948; Psort location: Cytoplasmic, score: 9.67.	0.999
KXA15702.1	RpsM	HMPREF3204_00967	HMPREF3204_00972	Ribosomal protein L15; KEGG: apb:SAR116_2410 9.9e-19 50S ribosomal protein L15 K02876.	KEGG: apb:SAR116_2413 8.9e-34 30S ribosomal protein S13 K02952; Psort location: Cytoplasmic, score: 9.97.	0.999
KXA15703.1	KXA15700.1	HMPREF3204_00968	HMPREF3204_00965	KEGG: apb:SAR116_2411 2.0e-82 preprotein translocase subunit SecY K03076; Psort location: CytoplasmicMembrane, score: 10.00.	Ribosomal protein S5; KEGG: apb:SAR116_2408 1.1e-35 30S ribosomal protein S5 K02988; Psort location: Cytoplasmic, score: 9.97.	0.999
KXA15703.1	KXA15702.1	HMPREF3204_00968	HMPREF3204_00967	KEGG: apb:SAR116_2411 2.0e-82 preprotein translocase subunit SecY K03076; Psort location: CytoplasmicMembrane, score: 10.00.	Ribosomal protein L15; KEGG: apb:SAR116_2410 9.9e-19 50S ribosomal protein L15 K02876.	0.996

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.814

expected number of edges:

31

PPI enrichment p-value:

0.42

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009102

Biotin biosynthetic process

4 of 6

2.29

2.43

2.01e-05

GO:0072330

Monocarboxylic acid biosynthetic process

5 of 30

1.68

1.98

2.19e-05

GO:0046394

Carboxylic acid biosynthetic process

6 of 107

1.21

1.17

0.00022

GO:0044281

Small molecule metabolic process

7 of 429

0.67

0.46

0.0126

GO:0071704

Organic substance metabolic process

10 of 1181

0.39

0.28

0.0258

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36584052

(2022) The inside scoop: Comparative genomics of two intranuclear bacteria, Candidatus Berkiella cookevillensis and Candidatus Berkiella aquae.

4 of 114

1.01

0.78

0.0028

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1111

Biotin metabolic process

4 of 5

2.37

2.7

6.44e-06

CL:1034

Mixed, incl. Vitamin biosynthetic process, and Coenzyme A metabolic process

5 of 45

1.51

1.59

9.73e-05

CL:842

Small molecule biosynthetic process, and Nucleotide biosynthetic process

6 of 141

1.09

0.97

0.00055

CL:1311

Phosphopantetheine, and Fatty acid synthase activity

2 of 5

2.06

0.85

0.0254

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00780

Biotin metabolism

5 of 26

1.75

2.32

3.19e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0093

Biotin biosynthesis

2 of 3

2.29

0.9

0.0221

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