STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
putAMethylmalonate-semialdehyde dehydrogenase; 247d0010; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)    
Predicted Functional Partners:
acs
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.935
acs-2
AMP-dependent synthetase; 97c0011; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.935
acs-3
AMP-dependent synthetase; 269d0010; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.935
acs-4
propionyl-CoA synthetase; 352d0013; catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl-and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.935
mmsB-2
3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; 252c0001; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.929
putA-4
Aldehyde dehydrogenase; 114c0002; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.
  
  
 
0.924
putA-5
Aldehyde dehydrogenase; 302c0015; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.
  
  
 
0.923
putA-7
Aldehyde dehydrogenase; 28c0009; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.923
fadB-2
3-hydroxyacyl-CoA dehydrogenase; 286d0006; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.922
mmsB-3
3-hydroxyisobutyrate dehydrogenase; 302d0013; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.913
Your Current Organism:
Methylobacterium aquaticum
NCBI taxonomy Id: 270351
Other names: CCM 7218, CECT 5998, CIP 108333, DSM 16371, M. aquaticum, Methylobacterium aquaticum Gallego et al. 2005, strain GR16
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