STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpA-2ATPases with chaperone activity, ATP-binding subunit; 308c0001; CDS was addded manually by using GenomeMatcher; Belongs to the ClpA/ClpB family. (875 aa)    
Predicted Functional Partners:
BAQ47411.1
EvpB family type VI secretion protein; 322c0010; Derived by automated computational analysis using gene prediction method: Protein Homology. Start codon location was manually corrected by using GenomeMatcher.
 
 
 0.958
BAR47236.1
Uncharacterized protein conserved in bacteria; 322c0009; Derived by automated computational analysis using Genaris Flexible Annotator.
 
 
 0.958
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 
 0.939
hcp
Uncharacterized hemolysin-coregulated protein; 270c0002; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.939
dnaK-3
2-alkenal reductase; 322c0002; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the heat shock protein 70 family.
 
 
 0.936
dnaK-2
Heat-shock protein; 195d0003; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.924
BAR47237.1
Uncharacterized protein conserved in bacteria; 322c0011; Derived by automated computational analysis using Genaris Flexible Annotator.
 
  
 0.916
vgrG
Uncharacterized protein conserved in bacteria; 137d0001; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.915
BAQ47412.1
Hypothetical protein; 322c0012; Derived by automated computational analysis using gene prediction method: Protein Homology. Start codon location was manually corrected by using GenomeMatcher.
 
  
 0.904
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
  
 
 0.887
Your Current Organism:
Methylobacterium aquaticum
NCBI taxonomy Id: 270351
Other names: CCM 7218, CECT 5998, CIP 108333, DSM 16371, M. aquaticum, Methylobacterium aquaticum Gallego et al. 2005, strain GR16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.