node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHK_0183 | CHK_1207 | CHK_0183 | CHK_1207 | DUF2225 domain-containing protein. | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.817 |
CHK_0183 | CHK_2189 | CHK_0183 | CHK_2189 | DUF2225 domain-containing protein. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.560 |
CHK_0183 | guaA | CHK_0183 | CHK_1158 | DUF2225 domain-containing protein. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.861 |
CHK_0183 | guaB | CHK_0183 | CHK_1160 | DUF2225 domain-containing protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.799 |
CHK_0183 | murI | CHK_0183 | CHK_0170 | DUF2225 domain-containing protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.574 |
CHK_0183 | purA | CHK_0183 | CHK_3105 | DUF2225 domain-containing protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.878 |
CHK_0183 | surE | CHK_0183 | CHK_2556 | DUF2225 domain-containing protein. | 5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.579 |
CHK_0862 | CHK_1207 | CHK_0862 | CHK_1207 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.842 |
CHK_0862 | CHK_2189 | CHK_0862 | CHK_2189 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.851 |
CHK_0862 | guaA | CHK_0862 | CHK_1158 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.918 |
CHK_0862 | guaB | CHK_0862 | CHK_1160 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.926 |
CHK_0862 | purA | CHK_0862 | CHK_3105 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.861 |
CHK_0862 | surE | CHK_0862 | CHK_2556 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.860 |
CHK_1206 | CHK_1207 | CHK_1206 | CHK_1207 | Phosphoesterase. | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.963 |
CHK_1206 | rph | CHK_1206 | CHK_1208 | Phosphoesterase. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.855 |
CHK_1207 | CHK_0183 | CHK_1207 | CHK_0183 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | DUF2225 domain-containing protein. | 0.817 |
CHK_1207 | CHK_0862 | CHK_1207 | CHK_0862 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.842 |
CHK_1207 | CHK_1206 | CHK_1207 | CHK_1206 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Phosphoesterase. | 0.963 |
CHK_1207 | CHK_2189 | CHK_1207 | CHK_2189 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.855 |
CHK_1207 | guaA | CHK_1207 | CHK_1158 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.971 |