CHK_2545 protein (Catabacter hongkongensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CHK_2545

Acetoin dehydrogenase E1 component beta-subunit. (821 aa)

Predicted Functional Partners:

CHK_0444

0.999

CHK_1042

0.999

CHK_2192

0.999

CHK_2254

0.999

CHK_2547

0.998

CHK_2724

0.996

CHK_0993

0.989

CHK_2382

0.989

CHK_2546

0.989

CHK_0623

0.988

Your Current Organism:

Catabacter hongkongensis

NCBI taxonomy Id: 270498
Other names: C. hongkongensis, CCUG 54229, Catabacter hongkongensis Lau et al. 2014, JCM 17853, strain HKU16

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
CHK_0444	CHK_0623	Lipoate-protein ligase A.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.710
CHK_0444	CHK_0993	Lipoate-protein ligase A.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.752
CHK_0444	CHK_1042	Lipoate-protein ligase A.	Dihydrolipoamide dehydrogenase.	0.999
CHK_0444	CHK_2192	Lipoate-protein ligase A.	Ribose-phosphate pyrophosphokinase.	0.734
CHK_0444	CHK_2254	Lipoate-protein ligase A.	Dihydrolipoamide dehydrogenase.	0.999
CHK_0444	CHK_2382	Lipoate-protein ligase A.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.737
CHK_0444	CHK_2545	Lipoate-protein ligase A.	Acetoin dehydrogenase E1 component beta-subunit.	0.999
CHK_0444	CHK_2546	Lipoate-protein ligase A.	Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex.	0.807
CHK_0444	CHK_2547	Lipoate-protein ligase A.	Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex.	0.732
CHK_0444	CHK_2724	Lipoate-protein ligase A.	Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex.	0.718
CHK_0623	CHK_0444	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Lipoate-protein ligase A.	0.710
CHK_0623	CHK_1042	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide dehydrogenase.	0.913
CHK_0623	CHK_2192	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Ribose-phosphate pyrophosphokinase.	0.680
CHK_0623	CHK_2254	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide dehydrogenase.	0.915
CHK_0623	CHK_2382	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.482
CHK_0623	CHK_2545	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Acetoin dehydrogenase E1 component beta-subunit.	0.988
CHK_0623	CHK_2546	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex.	0.883
CHK_0623	CHK_2724	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex.	0.491
CHK_0993	CHK_0444	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Lipoate-protein ligase A.	0.752
CHK_0993	CHK_1042	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide dehydrogenase.	0.915

page 1 of 5

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010693

Negative regulation of alkaline phosphatase activity

6 of 9

3.45

8.14

1.45e-15

GO:0043931

Ossification involved in bone maturation

6 of 12

3.32

7.95

2.69e-15

GO:0048843

Negative regulation of axon extension involved in axon guidance

7 of 78

2.58

6.82

2.19e-14

GO:0071526

Semaphorin-plexin signaling pathway

8 of 167

2.31

6.37

9.89e-15

GO:0001755

Neural crest cell migration

7 of 184

2.21

5.22

2.82e-12

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030215

Semaphorin receptor binding

7 of 76

2.59

6.69

4.55e-14

GO:0045499

Chemorepellent activity

7 of 97

2.48

6.34

1.16e-13

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005887

Integral component of plasma membrane

8 of 2789

1.08

1.13

3.16e-05

GO:0005615

Extracellular space

7 of 2286

1.11

1.12

8.61e-05

GO:0005886

Plasma membrane

10 of 11711

0.56

0.43

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:62160

Plexin repeat, and Semaphorin receptor complex

6 of 34

2.87

6.81

1.29e-13

CL:62158

Semaphorin-plexin signaling pathway

7 of 100

2.47

6.33

1.06e-13

CL:62145

Semaphorin-plexin signaling pathway

8 of 161

2.32

6.19

3.88e-14

CL:62161

Plexin repeat, and Semaphorin receptor complex

5 of 28

2.88

5.61

3.08e-11

CL:62163

Plexin repeat, and Semaphorin receptor complex

4 of 22

2.89

4.27

1.22e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-416700

Other semaphorin interactions

7 of 48

2.79

7.71

1.21e-15

MAP-416550

Sema4D mediated inhibition of cell attachment and migration

6 of 22

3.06

7.5

1.05e-14

MAP-416572

Sema4D induced cell migration and growth-cone collapse

6 of 38

2.82

6.77

1.24e-13

MAP-400685

Sema4D in semaphorin signaling

6 of 49

2.71

6.46

3.21e-13

MAP-373755

Semaphorin interactions

8 of 267

2.1

5.4

1.24e-13

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 27372

0.23

0.22

0.0268

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0393

Immunoglobulin domain

3 of 178

1.85

1.24

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001627

Sema domain

7 of 88

2.53

6.18

3.90e-13

IPR036352

Sema domain superfamily

7 of 92

2.51

6.15

3.90e-13

IPR027231

Semaphorin

6 of 64

2.6

5.55

1.43e-11

IPR002165

Plexin repeat

4 of 41

2.61

3.35

5.03e-07

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

7 of 594

1.7

2.76

4.61e-08

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00630

Semaphorin domain

6 of 63

2.6

5.86

3.34e-12

SM00423

Domain found in Plexins, Semaphorins and Integrins

4 of 73

2.36

3.09

9.66e-07

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

2 of 46

2.26

0.97

0.0161

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About