node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KRG28695.1 | KRG30745.1 | APR42_06795 | APR42_02465 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.753 |
KRG28695.1 | KRG30746.1 | APR42_06795 | APR42_02470 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.871 |
KRG28695.1 | folD | APR42_06795 | APR42_07100 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.474 |
KRG28695.1 | glyA | APR42_06795 | APR42_00200 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.669 |
KRG28695.1 | thyA | APR42_06795 | APR42_02435 | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.896 |
KRG30033.1 | KRG30745.1 | APR42_14795 | APR42_02465 | CMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.495 |
KRG30033.1 | KRG30746.1 | APR42_14795 | APR42_02470 | CMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.495 |
KRG30033.1 | dut | APR42_14795 | APR42_08245 | CMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.920 |
KRG30033.1 | tdk | APR42_14795 | APR42_14235 | CMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.908 |
KRG30033.1 | thyA | APR42_14795 | APR42_02435 | CMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.911 |
KRG30745.1 | KRG28695.1 | APR42_02465 | APR42_06795 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tetrahydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.753 |
KRG30745.1 | KRG30033.1 | APR42_02465 | APR42_14795 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | CMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.495 |
KRG30745.1 | KRG30746.1 | APR42_02465 | APR42_02470 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.977 |
KRG30745.1 | KRG30835.1 | APR42_02465 | APR42_02205 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | 0.418 |
KRG30745.1 | dut | APR42_02465 | APR42_08245 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.445 |
KRG30745.1 | folD | APR42_02465 | APR42_07100 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.442 |
KRG30745.1 | gcvT | APR42_02465 | APR42_04850 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.752 |
KRG30745.1 | glyA | APR42_02465 | APR42_00200 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.768 |
KRG30745.1 | tdk | APR42_02465 | APR42_14235 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.500 |
KRG30745.1 | thyA | APR42_02465 | APR42_02435 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.919 |