Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yhdH
neurotransmitter:Na+ symporter, NSS family; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (469 aa)
Predicted Functional Partners:
ldh
Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
0.468
Your Current Organism:
Pseudomonas xanthomarina
NCBI taxonomy Id: 271420 Other names: CCUG 46543, DSM 18231, JCM 12468, NRIC 0617, P. xanthomarina, Pseudomonas xanthomarina Romanenko et al. 2005