STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
AFZ59091.1Integral membrane sensor signal transduction histidine kinase; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterPro IPR003660:IPR003661:IPR003594; KEGG: npu:Npun_AR140 integral membrane sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; HAMP linker domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain; Signal [...] (622 aa)    
Predicted Functional Partners:
AFZ60403.1
PFAM: GAF domain; Response regulator receiver domain; COGs: COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain; InterPro IPR001789:IPR003018; KEGG: naz:Aazo_4317 response regulator receiver modulated GAF sensor protein; PFAM: Signal transduction response regulator, receiver domain; GAF; SMART: Signal transduction response regulator, receiver domain; SPTR: Response regulator receiver modulated GAF sensor protein.
  
 
   0.780
AFZ59090.1
TIGRFAM: phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; COGs: COG3221 ABC-type phosphate/phosphonate transport system periplasmic component; InterPro IPR005770:IPR001638; KEGG: cyt:cce_0690 phosphonate ABC transporter phosphate-binding protein; SMART: Extracellular solute-binding protein, family 3; SPTR: Phosphate-binding protein of phosphonate ABC transporter; TIGRFAM: Phosphonate-binding periplasmic protein.
       0.732
AFZ58170.1
Protein serine/threonine phosphatase with GAF(s) sensor(s); PFAM: Response regulator receiver domain; GAF domain; Stage II sporulation protein E (SpoIIE); COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001789:IPR003018:IPR010822:IPR001932; KEGG: naz:Aazo_2839 GAF(s) sensor(S)-containing protein serine phosphatase; PFAM: Sporulation stage II, protein E C-terminal; Signal transduction response regulator, receiver domain; GAF; SMART: Protein phosphatase 2C-like; GAF; Signal transduction response regulator, receiver domain; SPTR: Protein serine phosphatase wi [...]
 
 
 
 0.706
AFZ59628.1
Multi-component transcriptional regulator, winged helix family; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; Transcriptional regulatory protein, C terminal; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterProIPR001789:IPR001867:IPR003018:IPR000014:IPR 003661:IPR003594:IPR008207:IPR013767:IPR013955; KEGG: ava:Ava_0238 multi-component transcriptional regulator; PFAM [...]
 
 
0.621
AFZ58900.1
Signal transduction histidine kinase with CheB and CheR activity; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 
 0.612
AFZ60834.1
Adenylate/guanylate cyclase with GAF sensor(s); PFAM: Adenylate and Guanylate cyclase catalytic domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterProIPR001789:IPR003018:IPR003661:IPR003594:IPR 001054; KEGG: naz:Aazo_2338 GAF sensor-containing adenylate/guanylate cyclase; PFAM: ATPase-like, ATP-binding domain; GAF; Signal transduction response regulator, receiver domain; Signal transduction histidine kinase, subgroup 1, dimerisati [...]
 
 
0.574
AFZ60471.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR001789:IPR003018:IPR000014:IPR001610:IPR 003661:IPR003594:IPR013655:IPR013656; KEGG: naz:Aazo_4225 multi-sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction response regulator, receiver domain; GAF; PAS fold-3; PAS fold-4; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor d [...]
 
 
0.485
AFZ60420.1
Adenylate/guanylate cyclase with GAF and PAS/PAC sensors; PFAM: Adenylate and Guanylate cyclase catalytic domain; GAF domain; TIGRFAM: PAS domain S-box; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR003018:IPR000014:IPR001054; KEGG: naz:Aazo_2413 GAF/PAS/PAC sensor-containing adenylate/guanylate cyclase; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; GAF; PRIAM: Adenylate cyclase; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; GAF; PAS; SPTR: Adenylate/guanylate cyclase with GAF and PAS/PAC sensors.
 
 
 
 0.483
AFZ55839.1
PFAM: GAF domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR001789:IPR003018:IPR000014:IPR001610:IPR 003661:IPR003594:IPR013656:IPR013655:IPR013767; KEGG: ana:all4097 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-3; GAF; Signal transduction response regulator, receiver [...]
 
 
0.461
AFZ59542.1
PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000644:IPR003018:IPR000014:IPR001610:IPR 003661:IPR003594:IPR001789:IPR013767:IPR013656:IPR013655; KEGG: chl:Chy400_0428 multi-sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; GAF; Cystathionine beta-synthase, core; PAS f [...]
 
 
0.439
Your Current Organism:
Anabaena cylindrica
NCBI taxonomy Id: 272123
Other names: A. cylindrica PCC 7122, Anabaena cylindrica IAM M-1, Anabaena cylindrica NIES-19, Anabaena cylindrica PCC 7122, Anabaena cylindrica UTEX B 629, Anabaena sp. ATCC 27899, Anabaena sp. PCC 7122
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