STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
AFZ59566.1Multi-component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; Hpt domain; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867:IPR008207; KEGG: cyc:PCC7424_4548 multi-component transcriptional regulator, winged helix family; PFAM: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; Signal transduction histidine kinase, phosphotransfer (Hpt) domain; S [...] (612 aa)    
Predicted Functional Partners:
AFZ59916.1
Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG5002 Signal transduction histidine kinase; InterProIPR001789:IPR003018:IPR013767:IPR013656:IPR 013655:IPR003661:IPR003594:IPR000014:IPR001610; KEGG: cyj:Cyan7822_6041 multi-sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; GAF; Signal transduction response regulator, receiver domain; PAS fold; PAS fold-4; PAS [...]
 
 
 0.990
AFZ58959.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR003018:IPR013767:IPR003661:IPR 003594:IPR001789:IPR001610; KEGG: ava:Ava_4753 PAS/PAC sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; GAF; PAS fold; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; Signal transduction response regulator, receiver domain; SMART: ATPase-li [...]
 
 0.980
AFZ59628.1
Multi-component transcriptional regulator, winged helix family; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; Transcriptional regulatory protein, C terminal; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterProIPR001789:IPR001867:IPR003018:IPR000014:IPR 003661:IPR003594:IPR008207:IPR013767:IPR013955; KEGG: ava:Ava_0238 multi-component transcriptional regulator; PFAM [...]
 
 
0.980
AFZ59567.1
Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG5002 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003661:IPR003594:IPR 013655:IPR013767; KEGG: cyc:PCC7424_4549 multi-sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-3; PAS fold; SMART: ATPase-like, ATP-binding domain; Signal transductio [...]
 
 0.979
AFZ55839.1
PFAM: GAF domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR001789:IPR003018:IPR000014:IPR001610:IPR 003661:IPR003594:IPR013656:IPR013655:IPR013767; KEGG: ana:all4097 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-3; GAF; Signal transduction response regulator, receiver [...]
 
 
0.978
AFZ60471.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR001789:IPR003018:IPR000014:IPR001610:IPR 003661:IPR003594:IPR013655:IPR013656; KEGG: naz:Aazo_4225 multi-sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction response regulator, receiver domain; GAF; PAS fold-3; PAS fold-4; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor d [...]
 
 
0.978
AFZ60834.1
Adenylate/guanylate cyclase with GAF sensor(s); PFAM: Adenylate and Guanylate cyclase catalytic domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterProIPR001789:IPR003018:IPR003661:IPR003594:IPR 001054; KEGG: naz:Aazo_2338 GAF sensor-containing adenylate/guanylate cyclase; PFAM: ATPase-like, ATP-binding domain; GAF; Signal transduction response regulator, receiver domain; Signal transduction histidine kinase, subgroup 1, dimerisati [...]
 
 
0.978
AFZ55794.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; CHASE3 domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR003018:IPR000014:IPR003661:IPR003594:IPR 001789:IPR007891:IPR013767:IPR008207; KEGG: npu:Npun_R1685 multi-sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; CHASE3; GAF; PAS fold; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; Signal transduction response [...]
  
 
0.977
AFZ58647.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; Heme NO binding associated; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR013655:IPR003018:IPR003661:IPR003594:IPR 001789:IPR008207:IPR000014:IPR001610; KEGG: ana:alr2279 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; GAF; PAS fold-3; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; Signal transduction [...]
  
 
0.977
AFZ58900.1
Signal transduction histidine kinase with CheB and CheR activity; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
  
 
 0.977
Your Current Organism:
Anabaena cylindrica
NCBI taxonomy Id: 272123
Other names: A. cylindrica PCC 7122, Anabaena cylindrica IAM M-1, Anabaena cylindrica NIES-19, Anabaena cylindrica PCC 7122, Anabaena cylindrica UTEX B 629, Anabaena sp. ATCC 27899, Anabaena sp. PCC 7122
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