node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APE_0109.1 | fen | APE_0109.1 | APE_0115.1 | 5' to 3' nuclease repair protein NurA. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.501 |
APE_0109.1 | herA | APE_0109.1 | APE_0107 | 5' to 3' nuclease repair protein NurA. | Bipolar DNA helicase. | 0.959 |
APE_0109.1 | mre11 | APE_0109.1 | APE_0113 | 5' to 3' nuclease repair protein NurA. | Double-strand break repair protein MRE11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.768 |
APE_0109.1 | rad50 | APE_0109.1 | APE_0110 | 5' to 3' nuclease repair protein NurA. | DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.785 |
APE_0431 | APE_1323.1 | APE_0431 | APE_1323.1 | Hypothetical protein. | Single-stranded DNA binding protein; SSB. | 0.893 |
APE_0431 | APE_1353.1 | APE_0431 | APE_1353.1 | Hypothetical protein. | ATP-dependent helicase. | 0.888 |
APE_0431 | fen | APE_0431 | APE_0115.1 | Hypothetical protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.824 |
APE_0431 | lig | APE_0431 | APE_1094.1 | Hypothetical protein. | ADP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can also use ADP, but not NAD(+); Belongs to the ATP-dependent DNA ligase family. | 0.442 |
APE_0431 | mre11 | APE_0431 | APE_0113 | Hypothetical protein. | Double-strand break repair protein MRE11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.775 |
APE_0431 | rad50 | APE_0431 | APE_0110 | Hypothetical protein. | DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.748 |
APE_0431 | topA | APE_0431 | APE_1794 | Hypothetical protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.747 |
APE_1323.1 | APE_0431 | APE_1323.1 | APE_0431 | Single-stranded DNA binding protein; SSB. | Hypothetical protein. | 0.893 |
APE_1323.1 | APE_1353.1 | APE_1323.1 | APE_1353.1 | Single-stranded DNA binding protein; SSB. | ATP-dependent helicase. | 0.950 |
APE_1323.1 | fen | APE_1323.1 | APE_0115.1 | Single-stranded DNA binding protein; SSB. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.785 |
APE_1323.1 | lig | APE_1323.1 | APE_1094.1 | Single-stranded DNA binding protein; SSB. | ADP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can also use ADP, but not NAD(+); Belongs to the ATP-dependent DNA ligase family. | 0.742 |
APE_1323.1 | mre11 | APE_1323.1 | APE_0113 | Single-stranded DNA binding protein; SSB. | Double-strand break repair protein MRE11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.911 |
APE_1323.1 | rad50 | APE_1323.1 | APE_0110 | Single-stranded DNA binding protein; SSB. | DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.819 |
APE_1323.1 | radA | APE_1323.1 | APE_0119 | Single-stranded DNA binding protein; SSB. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). | 0.926 |
APE_1323.1 | topA | APE_1323.1 | APE_1794 | Single-stranded DNA binding protein; SSB. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.930 |
APE_1353.1 | APE_0431 | APE_1353.1 | APE_0431 | ATP-dependent helicase. | Hypothetical protein. | 0.888 |