Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
loxDD-lactate dehydrogenase. (473 aa)    
Predicted Functional Partners:
gyaR
Glyoxylate reductase.
   
 0.927
agt
Alanine glyoxylate transaminase.
    
 0.906
APE_0766
Phosphoglycolate phosphatase; Catalyzes the dephosphorylation of 2-phosphoglycolate.
    
  0.901
fni
Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 0.677
etfA
Electron transfer flavoprotein alpha-subunit.
  
 
 0.660
etfA-2
Electron transfer flavoprotein alpha-subunit.
  
 
 0.660
APE_0603
Molybdopterin converting factor; MoaD-MoaE fusion protein.
     
 0.613
etfB
Electron transfer flavoprotein beta-subunit.
  
 
 0.577
etfB-2
Electron transfer flavoprotein beta-subunit.
  
 
 0.577
APE_0159
Probable (S)-2,3-Di-O-farnesylgeranylglyceryl synthase.
    
 0.538
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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