STRINGSTRING
APE_0955 protein (Aeropyrum pernix) - STRING interaction network
"APE_0955" - Voltage-gated potassium channel in Aeropyrum pernix
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APE_0955Voltage-gated potassium channel; Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (295 aa)    
Predicted Functional Partners:
tmk
Putative thymidylate kinase; dTMP kinase (208 aa)
         
  0.781
argS
ArgRS; arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family (644 aa)
         
  0.731
tfe
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...] (189 aa)
           
  0.715
lig
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can also use ADP, but not NAD(+); Belongs to the ATP-dependent DNA ligase family (602 aa)
           
  0.703
nucS
Endonuclease NucS; Cleaves both 3’ and 5’ ssDNA extremities of branched DNA structures (261 aa)
              0.619
napA
annotation not available (363 aa)
         
  0.574
APE_0010.1
annotation not available (535 aa)
 
   
  0.548
APE_1478.1
annotation not available (221 aa)
 
          0.534
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5’-phosphoribosyl)-anthranilate (PRA) (345 aa)
 
        0.485
trkA
annotation not available (220 aa)
   
   
  0.448
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
Server load: low (23%) [HD]