node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APE_0322.1 | APE_1323.1 | APE_0322.1 | APE_1323.1 | Putative DNA repair helicase Rad3. | Single-stranded DNA binding protein; SSB. | 0.787 |
APE_0322.1 | APE_1353.1 | APE_0322.1 | APE_1353.1 | Putative DNA repair helicase Rad3. | ATP-dependent helicase. | 0.824 |
APE_0322.1 | APE_1436.1 | APE_0322.1 | APE_1436.1 | Putative DNA repair helicase Rad3. | Repair endonuclease XPF. | 0.799 |
APE_0322.1 | aspS | APE_0322.1 | APE_2192.1 | Putative DNA repair helicase Rad3. | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn) (By similarity). | 0.748 |
APE_0322.1 | fen | APE_0322.1 | APE_0115.1 | Putative DNA repair helicase Rad3. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.928 |
APE_0322.1 | mre11 | APE_0322.1 | APE_0113 | Putative DNA repair helicase Rad3. | Double-strand break repair protein MRE11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.913 |
APE_0322.1 | rad50 | APE_0322.1 | APE_0110 | Putative DNA repair helicase Rad3. | DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.697 |
APE_0322.1 | radA | APE_0322.1 | APE_0119 | Putative DNA repair helicase Rad3. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). | 0.659 |
APE_0322.1 | rfcL | APE_0322.1 | APE_1524.1 | Putative DNA repair helicase Rad3. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.740 |
APE_0322.1 | topA | APE_0322.1 | APE_1794 | Putative DNA repair helicase Rad3. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.766 |
APE_1323.1 | APE_0322.1 | APE_1323.1 | APE_0322.1 | Single-stranded DNA binding protein; SSB. | Putative DNA repair helicase Rad3. | 0.787 |
APE_1323.1 | APE_1353.1 | APE_1323.1 | APE_1353.1 | Single-stranded DNA binding protein; SSB. | ATP-dependent helicase. | 0.950 |
APE_1323.1 | APE_1436.1 | APE_1323.1 | APE_1436.1 | Single-stranded DNA binding protein; SSB. | Repair endonuclease XPF. | 0.923 |
APE_1323.1 | fen | APE_1323.1 | APE_0115.1 | Single-stranded DNA binding protein; SSB. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.785 |
APE_1323.1 | mre11 | APE_1323.1 | APE_0113 | Single-stranded DNA binding protein; SSB. | Double-strand break repair protein MRE11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.911 |
APE_1323.1 | rad50 | APE_1323.1 | APE_0110 | Single-stranded DNA binding protein; SSB. | DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.819 |
APE_1323.1 | radA | APE_1323.1 | APE_0119 | Single-stranded DNA binding protein; SSB. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). | 0.926 |
APE_1323.1 | rfcL | APE_1323.1 | APE_1524.1 | Single-stranded DNA binding protein; SSB. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.734 |
APE_1323.1 | topA | APE_1323.1 | APE_1794 | Single-stranded DNA binding protein; SSB. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.930 |
APE_1353.1 | APE_0322.1 | APE_1353.1 | APE_0322.1 | ATP-dependent helicase. | Putative DNA repair helicase Rad3. | 0.824 |