| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APE_0306.1 | APE_0681.1 | APE_0306.1 | APE_0681.1 | Putative carbohydrate kinase. | Conserved hypothetical protein. | 0.994 |
| APE_0306.1 | pan | APE_0306.1 | APE_2012 | Putative carbohydrate kinase. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.995 |
| APE_0306.1 | psmA | APE_0306.1 | APE_1449 | Putative carbohydrate kinase. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.901 |
| APE_0306.1 | psmB | APE_0306.1 | APE_0507.1 | Putative carbohydrate kinase. | Proteasome beta subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.901 |
| APE_0306.1 | psmB-2 | APE_0306.1 | APE_0521.1 | Putative carbohydrate kinase. | Proteasome beta subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.901 |
| APE_0306.1 | rpl40e | APE_0306.1 | APE_0113a | Putative carbohydrate kinase. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.899 |
| APE_0681.1 | APE_0306.1 | APE_0681.1 | APE_0306.1 | Conserved hypothetical protein. | Putative carbohydrate kinase. | 0.994 |
| APE_0681.1 | pan | APE_0681.1 | APE_2012 | Conserved hypothetical protein. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.998 |
| APE_0681.1 | psmA | APE_0681.1 | APE_1449 | Conserved hypothetical protein. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.898 |
| APE_0681.1 | psmB | APE_0681.1 | APE_0507.1 | Conserved hypothetical protein. | Proteasome beta subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.898 |
| APE_0681.1 | psmB-2 | APE_0681.1 | APE_0521.1 | Conserved hypothetical protein. | Proteasome beta subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.898 |
| APE_0681.1 | rad50 | APE_0681.1 | APE_0110 | Conserved hypothetical protein. | DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.712 |
| APE_0681.1 | rpl40e | APE_0681.1 | APE_0113a | Conserved hypothetical protein. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.941 |
| APE_2011.1 | hflX | APE_2011.1 | APE_2007 | Putative HTH-type transcriptional regulator. | Putative GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.878 |
| APE_2011.1 | pan | APE_2011.1 | APE_2012 | Putative HTH-type transcriptional regulator. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.815 |
| APE_2011.1 | rpl40e | APE_2011.1 | APE_0113a | Putative HTH-type transcriptional regulator. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.767 |
| APE_2153.1 | hflX | APE_2153.1 | APE_2007 | Erythrocyte band 7 integral membrane protein homolog. | Putative GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.778 |
| APE_2153.1 | pan | APE_2153.1 | APE_2012 | Erythrocyte band 7 integral membrane protein homolog. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.768 |
| hflX | APE_2011.1 | APE_2007 | APE_2011.1 | Putative GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | Putative HTH-type transcriptional regulator. | 0.878 |
| hflX | APE_2153.1 | APE_2007 | APE_2153.1 | Putative GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | Erythrocyte band 7 integral membrane protein homolog. | 0.778 |