STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (307 aa)    
Predicted Functional Partners:
hemB
Porphobilinogen synthase; ALADH; delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.998
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.997
cobA
uroporphyrin-III C-methyltransferase; SUMT; Belongs to the precorrin methyltransferase family.
  
 0.987
hemL-2
Glutamate-1-semialdehyde aminotransferase; GSA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
  
 0.973
hemD
Putative uroporphyrinogen-III synthase; UROS.
     
  0.900
hemL
Glutamate-1-semialdehyde aminotransferase; GSA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.812
fgs
Farnesylgeranyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.
  
  
 0.728
sirC
Precorrin-2 dehydrogenase.
 
  
 0.678
APE_0072
Heme exporter protein C.
 
  
 0.659
APE_2295.1
Conserved hypothetical protein.
       0.605
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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