node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BH1132 | leuA | gene:10727026 | gene:10728968 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.953 |
BH3061 | BH3873 | gene:10728971 | gene:10729786 | Acetolactate synthase large subunit; BH3061; incomplete. | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 0.920 |
BH3061 | bcaT | gene:10728971 | gene:10728054 | Acetolactate synthase large subunit; BH3061; incomplete. | Branched-chain amino acid aminotransferase; BH2156. | 0.541 |
BH3061 | ilvC | gene:10728971 | gene:10728969 | Acetolactate synthase large subunit; BH3061; incomplete. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |
BH3061 | ilvD | gene:10728971 | gene:10728972 | Acetolactate synthase large subunit; BH3061; incomplete. | Dihydroxy-acid dehydratase; BH3062; Belongs to the IlvD/Edd family. | 0.984 |
BH3061 | ilvN | gene:10728971 | gene:10728970 | Acetolactate synthase large subunit; BH3061; incomplete. | Acetolactate synthase small subunit; BH3060. | 0.999 |
BH3061 | leuA | gene:10728971 | gene:10728968 | Acetolactate synthase large subunit; BH3061; incomplete. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.981 |
BH3061 | leuB | gene:10728971 | gene:10728967 | Acetolactate synthase large subunit; BH3061; incomplete. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.983 |
BH3061 | leuC | gene:10728971 | gene:10728966 | Acetolactate synthase large subunit; BH3061; incomplete. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.861 |
BH3061 | leuD | gene:10728971 | gene:10728965 | Acetolactate synthase large subunit; BH3061; incomplete. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.864 |
BH3873 | BH3061 | gene:10729786 | gene:10728971 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase large subunit; BH3061; incomplete. | 0.920 |
BH3873 | bcaT | gene:10729786 | gene:10728054 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Branched-chain amino acid aminotransferase; BH2156. | 0.535 |
BH3873 | ilvC | gene:10729786 | gene:10728969 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.991 |
BH3873 | ilvD | gene:10729786 | gene:10728972 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; BH3062; Belongs to the IlvD/Edd family. | 0.928 |
BH3873 | ilvN | gene:10729786 | gene:10728970 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase small subunit; BH3060. | 0.998 |
BH3873 | leuA | gene:10729786 | gene:10728968 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.954 |
BH3873 | leuB | gene:10729786 | gene:10728967 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.974 |
BH3873 | leuC | gene:10729786 | gene:10728966 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.677 |
BH3873 | leuD | gene:10729786 | gene:10728965 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.755 |
bcaT | BH3061 | gene:10728054 | gene:10728971 | Branched-chain amino acid aminotransferase; BH2156. | Acetolactate synthase large subunit; BH3061; incomplete. | 0.541 |