node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BH0026 | BH3453 | gene:10725844 | gene:10729366 | Nucleotidase precursor; Belongs to the 5'-nucleotidase family. | BH3453; unknown conserved protein; Belongs to the 5'-nucleotidase family. | 0.926 |
BH0026 | comEB | gene:10725844 | gene:10727228 | Nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Late competence operon required for DNA binding and uptake; BH1334. | 0.906 |
BH0026 | tdk | gene:10725844 | gene:10729692 | Nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Thymidine kinase; BH3779. | 0.932 |
BH0026 | thyB | gene:10725844 | gene:10729364 | Nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.904 |
BH0026 | tmk | gene:10725844 | gene:10725864 | Nucleotidase precursor; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.912 |
BH1629 | BH2816 | gene:10727527 | gene:10728716 | BH1629; unknown conserved protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.959 |
BH1629 | dfrA | gene:10727527 | gene:10729363 | BH1629; unknown conserved protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.941 |
BH1629 | folD | gene:10727527 | gene:10728684 | BH1629; unknown conserved protein. | Methylenetetrahydrofolate dehydrogenase(NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.950 |
BH1629 | glyA | gene:10727527 | gene:10729678 | BH1629; unknown conserved protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |
BH1629 | thyB | gene:10727527 | gene:10729364 | BH1629; unknown conserved protein. | Thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.945 |
BH2816 | BH1629 | gene:10728716 | gene:10727527 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | BH1629; unknown conserved protein. | 0.959 |
BH2816 | dfrA | gene:10728716 | gene:10729363 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.925 |
BH2816 | folD | gene:10728716 | gene:10728684 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Methylenetetrahydrofolate dehydrogenase(NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.967 |
BH2816 | glyA | gene:10728716 | gene:10729678 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
BH2816 | thyB | gene:10728716 | gene:10729364 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.930 |
BH3453 | BH0026 | gene:10729366 | gene:10725844 | BH3453; unknown conserved protein; Belongs to the 5'-nucleotidase family. | Nucleotidase precursor; Belongs to the 5'-nucleotidase family. | 0.926 |
BH3453 | comEB | gene:10729366 | gene:10727228 | BH3453; unknown conserved protein; Belongs to the 5'-nucleotidase family. | Late competence operon required for DNA binding and uptake; BH1334. | 0.905 |
BH3453 | dfrA | gene:10729366 | gene:10729363 | BH3453; unknown conserved protein; Belongs to the 5'-nucleotidase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.479 |
BH3453 | tdk | gene:10729366 | gene:10729692 | BH3453; unknown conserved protein; Belongs to the 5'-nucleotidase family. | Thymidine kinase; BH3779. | 0.916 |
BH3453 | thyB | gene:10729366 | gene:10729364 | BH3453; unknown conserved protein; Belongs to the 5'-nucleotidase family. | Thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.945 |