STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptsHPhosphocarrier protein HPr; Similar to Escherichia coli Salmonella typhimurium, and Salmonella typhi phosphocarrier protein HPr or PtsH SWALL:PTHP_ECOLI (SWALL:P07006) (85 aa) fasta scores: E(): 3.2e-08, 40.96% id in 83 aa, and to Alcaligenes eutrophus phosphocarrier protein hpr phbH SWALL:PTHP_ALCEU (SWALL:P23537) (89 aa) fasta scores: E(): 2.8e-26, 79.77% id in 89 aa. (89 aa)    
Predicted Functional Partners:
BPSL0498
Similar to Pseudomonas aeruginosa probable phosphotransferase protein pa3760 SWALL:Q9HXN5 (EMBL:AE004794) (842 aa) fasta scores: E(): 8e-102, 49.53% id in 860 aa. C-terminus is similar to the C-terminal region of Rhodobacter capsulatus multiphosphoryl transfer protein frub(hi) SWALL:PTF1_RHOCA (SWALL:P23388) (827 aa) fasta scores: E(): 2.7e-78, 40.73% id in 739 aa; Belongs to the PEP-utilizing enzyme family.
 
 0.999
BPSL0440
Putative phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
 0.997
BPSL0438
Sugar transport PTS system IIa component; Similar to the N-terminal region of Escherichia coli PTS system, mannose-specific IIab component ManX or PtsL or GptB SWALL:PTNA_ECOLI (SWALL:P08186) (322 aa) fasta scores: E(): 0.00046, 32.46% id in 154 aa, and to the full length Ralstonia solanacearum hypothetical protein rsc0346 or rs03313 SWALL:Q8Y2J0 (EMBL:AL646058) (169 aa) fasta scores: E(): 1.2e-23, 63.28% id in 128 aa. CDS is truncated at the N-terminus in comparison to the R. solanacearum protein, but is a similar length to other orthologues.
 
 
 0.992
BPSL0499
Phosphotransferase system, IIbc component; N-terminus is similar to the N-terminal region of Escherichia coli PTS system, N-acetylglucosamine-specific IIabc component NagE or PstN SWALL:PTAA_ECOLI (SWALL:P09323) (648 aa) fasta scores: E(): 1.2e-88, 52.51% id in 516 aa. Full length CDS is similar to Pseudomonas aeruginosa probable phosphotransferase system protein pa3761 SWALL:Q9HXN4 (EMBL:AE004794) (570 aa) fasta scores: E(): 1.2e-85, 56.15% id in 577 aa.
 
 
 0.967
BPSS1150
Similar to Alcaligenes eutrophus phosphocarrier protein Hpr phbH SWALL:PTHP_ALCEU (SWALL:P23537) (89 aa) fasta scores: E(): 4.2e-05, 39.13% id in 69 aa, and to Ralstonia solanacearum probable phosphocarrier protein Hpr PstH or rsc0347 or rs03314 SWALL:Q8Y2I9 (EMBL:AL646058) (89 aa) fasta scores: E(): 9.4e-05, 38.37% id in 86 aa.
  
  
0.906
BPSL0531
Similar to Escherichia coli nitrogen regulatory IIA protein PtsN or RpoP SWALL:PTSN_ECOLI (SWALL:P31222) (163 aa) fasta scores: E(): 1.9e-13, 36.3% id in 146 aa, and to Ralstonia solanacearum putative nitrogen regulatory IIA rsc0406 or rs03374 SWALL:Q8Y2D0 (EMBL:AL646059) (151 aa) fasta scores: E(): 2.6e-44, 78.14% id in 151 aa.
 
  
 0.881
hprK
Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
 
 
 
 0.866
lptA
OstA-like protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane.
  
  
 0.714
BPSS1957
Similar to Escherichia coli 6-phosphofructokinase isozyme 2 PfkB or b1723 SWALL:K6P2_ECOLI (SWALL:P06999) (309 aa) fasta scores: E(): 1.8e-31, 39.48% id in 309 aa, and to Salmonella typhimurium 6-phosphofructokinase II Pfkb or stm1326 SWALL:Q8ZPT5 (EMBL:AE008757) (310 aa) fasta scores: E(): 7e-32, 39.15% id in 309 aa; Belongs to the carbohydrate kinase PfkB family.
 
  
 0.634
rpsG
30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
  
    0.610
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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