STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mutMPutative formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (276 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.974
mutY
Putative A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
 
  
 0.887
BPSL2556
Possible DNA polymerase/helicase; Similar to Bacillus halodurans DNA polymerase III PolC-type PolC or bh2418 SWALL:DPO3_BACHD (SWALL:Q9KA72) (1433 aa) fasta scores: E(): 1.1e-12, 35.54% id in 166 aa, and to Neisseria meningitidis DNA polymerase III, epsilon subunit nmb1451 SWALL:Q9JYS6 (EMBL:AE002495) (470 aa) fasta scores: E(): 2.2e-27, 42.35% id in 229 aa, and to Bacillus subtilis probable ATP-dependent helicase DinG homolog dinG SWALL:DING_BACSU (SWALL:P54394) (931 aa) fasta scores: E(): 7.6e-14, 38.79% id in 183 aa.
  
  
 0.844
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.784
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
   
  
 0.717
BPSS1291
Putative DEAD/DEAH box helicase; Similar to Pseudomonas aeruginosa probable ATP-dependent DNA helicase pa3272 SWALL:Q9HYW9 (EMBL:AE004749) (1448 aa) fasta scores: E(): 4.7e-132, 63.01% id in 1598 aa, and to Xanthomonas axonopodis ATP-dependent DNA helicase Lhr1 or xac2450 SWALL:AAM37301 (EMBL:AE011882) (1480 aa) fasta scores: E(): 1.3e-123, 57.92% id in 1597 aa.
  
  
 0.706
uvrC
Putative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
  
  
 0.647
LolB
Putative lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
       0.614
ruvB
Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
   
 0.608
BPSL0525
Putative membrane protein; Similar to Ralstonia solanacearum hypothetical transmembrane protein rsc0398 or rs03366 SWALL:Q8Y2D8 (EMBL:AL646059) (642 aa) fasta scores: E(): 2.2e-43, 41.42% id in 630 aa> C-terminus is similar to the C-terminal region of Pseudomonas aeruginosa hypothetical protein pa4667 SWALL:YAG7_PSEAE (SWALL:P42810) (590 aa) fasta scores: E(): 1.7e-38, 30.1% id in 558 aa.
       0.598
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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