STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fur-2Putative Fur family transcriptional regulator; Similar to Escherichia coli zinc uptake regulation protein Zur or b4046 SWALL:ZUR_ECOLI (SWALL:P32692) (171 aa) fasta scores: E(): 2.7e-12, 33.57% id in 137 aa, and to Pseudomonas aeruginosa transcriptional regulator Np20 or pa5499 SWALL:Q9HT74 (EMBL:AE004962) (167 aa) fasta scores: E(): 6e-21, 42.17% id in 147 aa. Possible alternative translational start sites; Belongs to the Fur family. (154 aa)    
Predicted Functional Partners:
BPSL0976
Similar to Ralstonia solanacearum probable outer membrane receptor protein rsc2400 or rs02718 SWALL:Q8XWS0 (EMBL:AL646070) (621 aa) fasta scores: E(): 5.2e-91, 49.1% id in 615 aa, and to Salmonella typhimurium vitamin B12 receptor precursor BtuB or stm4130 SWALL:BTUB_SALTY (SWALL:P37409) (614 aa) fasta scores: E(): 2.7e-32, 28.52% id in 603 aa. CDS is extended at the N-terminus in comparison to orthologues.
      
 0.722
fur
Ferric uptake regulator; Previously sequenced as Burkholderia pseudomallei ferric uptake regulator Fur SWALL:Q9Z5Z9 (EMBL:AF117238) (142 aa) fasta scores: E(): 8.2e-57, 100% id in 142 aa. Highly similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 ferric uptake regulation protein Fur or b0683 or c0770 or z0831 or ecs0714 SWALL:FUR_ECOLI (SWALL:P06975) (148 aa) fasta scores: E(): 8.1e-29, 55% id in 140 aa; Belongs to the Fur family.
     
 0.719
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.711
BPSL0822
Similar to Mycobacterium leprae putative ABC-transporter transmembrane protein ml0335 SWALL:Q9CCW1 (EMBL:AL583918) (286 aa) fasta scores: E(): 6.6e-22, 35.63% id in 261 aa, and to Thermoanaerobacter tengcongensis ABC-type Mn2+/Zn2+ transport systems, permease components znuB or tte0361 SWALL:Q8RCQ5 (EMBL:AE013009) (263 aa) fasta scores: E(): 2.3e-20, 32.03% id in 256 aa.
  
  
 0.697
BPSL0824
Similar to Yersinia pestis periplasmic chelated iron-binding protein YfeA or ypo2439 or y1897 SWALL:YFEA_YERPE (SWALL:Q56952) (311 aa) fasta scores: E(): 3.9e-08, 31.05% id in 219 aa, and to Mycobacterium tuberculosis hypothetical protein rv2059 or mtcy63a.01c or mt2119 SWALL:O07257 (EMBL:Z97984) (511 aa) fasta scores: E(): 2.2e-19, 34.41% id in 247 aa.
  
  
 0.649
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
   0.574
rpoC
DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
   0.567
rpoZ
DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
 
 0.563
BPSL3393
Conserved hypothetical protein; Similar to many hypotheticals though shorter in the N-terminus. Similar to Ralstonia solanacearum hypothetical protein Rsc3313 or Rs02543 SWALL:Q8XU80 (EMBL:AL646074) (153 aa) fasta scores: E(): 3.7e-14, 52.47% id in 101 aa, and to Escherichia coli protein YccU or b0965 SWALL:YCCU_ECOLI (SWALL:P75874) (137 aa) fasta scores: E(): 1.8e-11, 46.8% id in 94 aa. Possible gene remnant.
  
    0.561
BPSL1782
Putative iron transport-related membrane protein; Similar to Escherichia coli ferric iron reductase protein FhuF or b4367 SWALL:FHUF_ECOLI (SWALL:P39405) (262 aa) fasta scores: E(): 4.7e-06, 27.27% id in 242 aa, and to Rhizobium meliloti putative transport protein r02270 or smc01658 SWALL:Q92ND8 (EMBL:AL591790) (243 aa) fasta scores: E(): 1.2e-06, 27.31% id in 238 aa.
  
   
 0.554
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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