STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
nadDPutative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (250 aa)    
Predicted Functional Partners:
rsfS
Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
 
  
 0.960
BPSL2962
Putative competence-damaged related protein; Similar to Escherichia coli, and Escherichia coli O6 protein YgaD or b2700 or c3254 SWALL:YGAD_ECOLI (SWALL:P41053) (165 aa) fasta scores: E(): 1.1e-26, 54.48% id in 156 aa, and to Ralstonia solanacearum hypothetical protein rsc2770 or rs00077 SWALL:Q8XVQ9 (EMBL:AL646071) (166 aa) fasta scores: E(): 1.7e-37, 65.45% id in 165 aa; Belongs to the CinA family.
 
 
 0.955
nadE-2
Putative glutamine-dependent NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.952
nadK
Putative ATP-NAD kinase/inorganic polyphosphatase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.942
nadC
Putative nicotinate-nucleotide pyrophosphorylase; Similar to Burkholderia cepacia phthalate-inducible quinolinate phosphoribosyl transferase OphE SWALL:Q9ZFQ8 (EMBL:AF095748) (281 aa) fasta scores: E(): 5.5e-59, 61.76% id in 272 aa, and to Ralstonia solanacearum probable nicotinate-nucleotide pyrophosphorylase NadC or rsc2448 or rs01158 SWALL:Q8XWM6 (EMBL:AL646070) (295 aa) fasta scores: E(): 2.1e-71, 68.36% id in 294 aa; Belongs to the NadC/ModD family.
    
 0.938
nadE
Putative NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
 
 0.938
BPSL0717
Conserved hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
 
 
 0.936
pncB
Putative nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family.
  
 
 0.927
pntAB
NAD(P) transhydrogenase subunit alpha; Similar to the C-terminal region of Escherichia coli NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2) PntA or b1603 SWALL:PNTA_ECOLI (SWALL:P07001) (510 aa) fasta scores: E(): 4.5e-12, 58.53% id in 82 aa, and to Ralstonia solanacearum probable transmembrane NAD(P) transhydrogenase subunit alpha rsc2732 or rs00122 SWALL:Q8XVU5 (EMBL:AL646071) (107 aa) fasta scores: E(): 9.1e-26, 80.61% id in 98 aa.
     
 0.909
pntAA
NAD(P) transhydrogenase subunit alpha; Similar to the N-terminal region of Escherichia coli NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2) PntA or b1603 SWALL:PNTA_ECOLI (SWALL:P07001) (510 aa) fasta scores: E(): 4.9e-42, 44.85% id in 379 aa, and to Ralstonia solanacearum probable NAD(P) transhydrogenase subunit alpha rsc2730 or rs00124 SWALL:Q8XVU7 (EMBL:AL646071) (379 aa) fasta scores: E(): 3.6e-92, 72.75% id in 378 aa.
     
 0.909
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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