STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
surEAcid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa)    
Predicted Functional Partners:
deoA
Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
    
 0.969
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
  
  
 0.963
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
     
 0.958
pyrR
Bifunctional regulator/uracil phosphoribosyltransferase; Similar to Bacillus caldolyticus PyrR bifunctional protein [includes: pyrimidine operon regulatory protein; uracil phosphoribosyltransferase] SWALL:PYRR_BACCL (SWALL:P41007) (179 aa) fasta scores: E(): 2.1e-14, 41.61% id in 161 aa, and to Pseudomonas aeruginosa PyrR bifunctional protein [includes: pyrimidine operon regulatory protein; uracil phosphoribosyltransferase pyrr or pa0403 SWALL:Q9X6W6 (EMBL:AF148692) (170 aa) fasta scores: E(): 2.7e-21, 47.02% id in 151 aa.
     
 0.955
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
    
 0.951
BPSS1106
Putative thymidylate synthase protein; Similar to Bacteriophage SP01 deoxyuridylate hydroxymethyltransferase 29 SWALL:DUHM_BPSP1 (SWALL:P31654) (383 aa) fasta scores: E(): 6.8e-12, 30.04% id in 223 aa, and to Rhizobium loti thymidylate synthase ThyA or mll1467 SWALL:Q98KH9 (EMBL:AP002997) (264 aa) fasta scores: E(): 8e-08, 24.05% id in 237 aa, and to Agrobacterium tumefaciens thymidylate synthase ThyA or atu2047 or agr_c_3709 SWALL:Q8UDS3 (EMBL:AE009155) (279 aa) fasta scores: E(): 6.8e-07, 23.72% id in 236 aa.
   
 
 0.945
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.943
pcm-2
Putative L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
  
 0.942
thyA
Putative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
   
 
 0.938
cmk
Cytidylate kinase; Similar to Escherichia coli, and Escherichia coli O157:H7 cytidylate kinase cmk or mssa or b0910 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 1.3e-36, 53.91% id in 217 aa, and to Bordetella bronchiseptica cytidylate kinase cmK SWALL:KCY_BORBR (SWALL:Q9RND6) (223 aa) fasta scores: E(): 2.6e-43, 62.26% id in 212 aa.
    
 0.933
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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