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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Score
sucBDihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (425 aa)    
Predicted Functional Partners:
sucA
2-oxoglutarate dehydrogenase E1 component; Similar to Escherichia coli, and Escherichia coli O157:H7 2-oxoglutarate dehydrogenase E1 component SucA or b0726 or z0880 or ecs0751 SWALL:ODO1_ECOLI (SWALL:P07015) (933 aa) fasta scores: E(): 1.8e-205, 55.07% id in 946 aa, and to Alcaligenes eutrophus 2-oxoglutarate dehydrogenase E1 component OdhA SWALL:ODO1_ALCEU (SWALL:Q59106) (950 aa) fasta scores: E(): 0, 77.39% id in 951 aa.
 0.999
odhL
Similar to Alcaligenes eutrophus dihydrolipoamide dehydrogenase OdhL SWALL:DLDH_ALCEU (SWALL:P52992) (474 aa) fasta scores: E(): 9.7e-132, 76.93% id in 477 aa, and to Ralstonia solanacearum probable dihydrolipoamide dehydrogenase rsc1271 or rs02809 SWALL:Q8XZX4 (EMBL:AL646063) (478 aa) fasta scores: E(): 2.9e-134, 77.35% id in 477 aa.
 0.998
lpdV
Similar to Pseudomonas putida dihydrolipoamide dehydrogenase LpdV SWALL:DLD1_PSEPU (SWALL:P09063) (459 aa) fasta scores: E(): 9.9e-115, 69.09% id in 466 aa, and to Pseudomonas aeruginosa lipoamide dehydrogenase-Val pa2250 SWALL:Q9I1L9 (EMBL:AE004650) (464 aa) fasta scores: E(): 2.6e-123, 71.24% id in 466 aa.
 0.995
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.986
BPSL2299
Putative dihydrolipoamide dehydrogenase; C-terminal region is similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 dihydrolipoamide dehydrogenase LpdA or Lpd SWALL:DLDH_ECOLI (SWALL:P00391) (473 aa) fasta scores: E(): 1.9e-93, 65.75% id in 473 aa. Full length CDS is similar to Ralstonia solanacearum probable dihydrolipoamide dehydrogenase rsc1603 or rs03965 SWALL:Q8XZ03 (EMBL:AL646065) (594 aa) fasta scores: E(): 2.1e-142, 76.88% id in 597 aa.
0.985
sucD
succinyl-CoA ligase alpha-chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.983
bkdA2
Similar to Pseudomonas putida 2-oxoisovalerate dehydrogenase beta subunit BkdA2 SWALL:ODBB_PSEPU (SWALL:P09061) (339 aa) fasta scores: E(): 3.9e-125, 87.83% id in 337 aa, and to Pseudomonas aeruginosa 2-oxoisovalerate dehydrogenase pa2248 SWALL:Q9I1M1 (EMBL:AE004650) (350 aa) fasta scores: E(): 4.7e-122, 82.37% id in 346 aa. Possible alternative translational start site.
 
 0.980
bkdA1
Similar to Pseudomonas putida 2-oxoisovalerate dehydrogenase alpha subunit BkdA1 SWALL:ODBA_PSEPU (SWALL:P09060) (410 aa) fasta scores: E(): 1.6e-139, 80% id in 410 aa, and to Pseudomonas aeruginosa 2-oxoisovalerate dehydrogenase pa2247 SWALL:Q9I1M2 (EMBL:AE004650) (410 aa) fasta scores: E(): 6.2e-145, 83.9% id in 410 aa.
 
 0.924
BPSS0514
acetyl-CoA hydrolase/transferase; Similar to Clostridium kluyveri succinyl-CoA:coenzyme A transferase Cat1 SWALL:CAT1_CLOKL (SWALL:P38946) (538 aa) fasta scores: E(): 2e-97, 51.73% id in 520 aa, and to Xanthomonas campestris coa tranferase xcc3588 SWALL:Q8P4W8 (EMBL:AE012479) (504 aa) fasta scores: E(): 1.2e-133, 68.52% id in 502 aa. Possible alternative translational start sites.
   
 0.915
BPSL2747
Putative glutaryl-CoA dehydrogenase; Similar to Prokaryotic and Eukaryotic dehydrogenases including: Rhizobium meliloti putative glutaryl-CoA dehydrogenase protein rb0847 or smb21181 SWALL:Q92V67 (EMBL:AL603645) (395 aa) fasta scores: E(): 7.9e-118, 72.98% id in 396 aa and to Homo sapiens glutaryl-CoA dehydrogenase, mitochondrial precursor GcdH SWALL:GCDH_HUMAN (SWALL:Q92947) (438 aa) fasta scores: E(): 1.9e-100, 64.6% id in 404 aa.
   
  0.914
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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