Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
galUUTP--glucose-1-phosphate uridylyltransferase; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri UTP--glucose-1-phosphate uridylyltransferase GalU or b1236 or z2012 or ecs1738 SWALL:GALU_ECOLI (SWALL:P25520) (301 aa) fasta scores: E(): 5.6e-51, 54.82% id in 290 aa, and to Burkholderia pseudomallei putative UTP-glucose-1-phosphate uridylyltransferase SWALL:Q9F5N4 (EMBL:AF312223) (295 aa) fasta scores: E(): 2.7e-92, 83.91% id in 286 aa. (293 aa)    
Predicted Functional Partners:
udg2
UDP-glucose 6-dehydrogenase 2; Similar to Pseudomonas aeruginosa UDP-glucose 6-dehydrogenase Udg or Ugd or pa2022 SWALL:UDG_PSEAE (SWALL:O86422) (453 aa) fasta scores: E(): 5.7e-83, 51.97% id in 456 aa, and to Rhizobium meliloti UDP-glucose 6-dehydrogenase RkpK or r01082 or smc02641 SWALL:UDG_RHIME (SWALL:O54068) (437 aa) fasta scores: E(): 2.8e-70, 49.66% id in 453 aa. Note: Also similar to BPSL2511 Udg (467 aa) fasta scores: E(): 1.5e-121, 76.304% identity in 460 aa overlap.
  
 0.947
udg
Putative UDP-glucose dehydrogenase; Highly similar to the previously sequenced Burkholderia pseudomallei putative UDP-glucose dehydrogenase Udg SWALL:Q9WWX8 (EMBL:AF159428) (466 aa) fasta scores: E(): 1.1e-178, 99.35% id in 466 aa, and to Pseudomonas aeruginosa UDP-glucose 6-dehydrogenase Udg or pa2022 SWALL:UDG_PSEAE (SWALL:O86422) (453 aa) fasta scores: E(): 2.6e-86, 53.39% id in 457 aa. Note: Also similar to BPSS1833 (474 aa) fasta scores: E(): 1.5e-121, 76.304% identity in 460 aa overlap.
  
 0.945
pgm
Phosphoglucomutase; Similar to Neisseria meningitidis phosphoglucomutase Pgm or nmb0790 SWALL:PGMU_NEIMB (SWALL:P40391) (460 aa) fasta scores: E(): 1.2e-98, 56% id in 466 aa and to Ralstonia solanacearum putative phosphomannomutase or phosphoglucomutase protein rsc0691 or rs01596 SWALL:Q8Y1J9 (EMBL:AL646060) (461 aa) fasta scores: E(): 1.6e-123, 68.46% id in 463 aa.
   
 0.936
BPSL2670
UDP-glucose 4-epimerase; Previously sequenced as Burkholderia pseudomallei putative UDP-glucose 4-epimerase SWALL:O69132 (EMBL:AF064070) (340 aa) fasta scores: E(): 3.1e-125, 100% id in 340 aa and similar to Bacillus subtilis UDP-glucose 4-epimerase GalE SWALL:GALE_BACSU (SWALL:P55180) (339 aa) fasta scores: E(): 6.8e-80, 65.16% id in 333 aa; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
 
  
 0.935
rmlA
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
  
 
0.920
otsA
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D- glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose- 6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor; Belongs to the glycosyltransferase 20 family.
    
 0.911
otsA-2
Alpha,alpha-trehalose-phosphate synthase; Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D- glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose- 6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor; Belongs to the glycosyltransferase 20 family.
    
 0.911
bcsA
Similar to Escherichia coli O157:H7 cellulose synthase catalytic subunit [UDP-forming] BcsA or z4948 or ecs4413 SWALL:Q8X5L7 (EMBL:AE005579) (888 aa) fasta scores: E(): 1.6e-156, 48.61% id in 833 aa, and to Salmonella typhimurium cellulose synthase catalytic subunit [udp-forming] bcsa or stm3619 SWALL:Q93IN2 (EMBL:AJ315770) (874 aa) fasta scores: E(): 2.1e-156, 48.03% id in 816 aa.
  
 
 0.909
BPSL2079
Similar to Escherichia coli 4-alpha-glucanotransferase MalQ or MalA or b3416 SWALL:MALQ_ECOLI (SWALL:P15977) (694 aa) fasta scores: E(): 8.2e-51, 31.39% id in 739 aa, and to Ralstonia solanacearum putative 4-alpha-glucanotransferase rsp0236 or rs05187 SWALL:Q8XT79 (EMBL:AL646077) (774 aa) fasta scores: E(): 1.3e-81, 47.12% id in 783 aa.
     
 0.908
rfbF
Similar to Salmonella typhimurium glucose-1-phosphate cytidylyltransferase RfbF or stm2092 SWALL:RFBF_SALTY (SWALL:P26396) (257 aa) fasta scores: E(): 4e-73, 68.09% id in 257 aa, and to Yersinia enterocolitica DdhA SWALL:Q56860 (EMBL:U46859) (261 aa) fasta scores: E(): 9e-74, 66.14% id in 257 aa.
    
 0.908
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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