Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
BPSL2002Putative iron-containing alcohol dehydrogenase; Similar to Citrobacter freundii 1,3-propanediol dehydrogenase DhaT SWALL:DHAT_CITFR (SWALL:P45513) (387 aa) fasta scores: E(): 5.4e-34, 36.79% id in 375 aa, to Bacillus subtilis alcohol dehydrogenase GbsB SWALL:GBSB_BACSU (SWALL:P71017) (402 aa) fasta scores: E(): 1e-28, 33.42% id in 371 aa, and to Ralstonia solanacearum probable NAD-dependent 4-hydroxybutyrate dehydrogenase oxidoreductase protein rsc1771 or rs02958 SWALL:Q8XYI7 (EMBL:AL646066) (382 aa) fasta scores: E(): 5.7e-117, 80.89% id in 382 aa. (382 aa)    
Predicted Functional Partners:
gabD
Similar to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD or b2661 SWALL:GABD_ECOLI (SWALL:P25526) (482 aa) fasta scores: E(): 2e-126, 66.45% id in 480 aa, and to Pseudomonas aeruginosa succinate-semialdehyde dehydrogenase pa0265 SWALL:Q9I6M5 (EMBL:AE004464) (483 aa) fasta scores: E(): 1e-130, 69.03% id in 478 aa.
  
 0.923
gabD-2
Similar to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD or b2661 SWALL:GABD_ECOLI (SWALL:P25526) (482 aa) fasta scores: E(): 1.4e-130, 69.7% id in 482 aa, and to Salmonella typhi succinate-semialdehyde dehydrogenase sty2911 SWALL:Q8Z4F8 (EMBL:AL627276) (482 aa) fasta scores: E(): 7.2e-131, 70.12% id in 482 aa.
  
 0.923
gabT
Similar to Escherichia coli 4-aminobutyrate aminotransferase GabT or b2662 SWALL:GABT_ECOLI (SWALL:P22256) (426 aa) fasta scores: E(): 4.8e-79, 54.24% id in 424 aa, and to Ralstonia solanacearum probable 4-aminobutyrate aminotransferase protein rsc0029 or rs01852 SWALL:Q8Y3F1 (EMBL:AL646057) (426 aa) fasta scores: E(): 1.5e-108, 71.29% id in 418 aa; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.913
flhA
Similar to Paracoccus denitrificans glutathione-dependent formaldehyde dehydrogenase FlhA SWALL:FADH_PARDE (SWALL:P45382) (375 aa) fasta scores: E(): 1e-108, 75.2% id in 375 aa, and to Ralstonia solanacearum probable bifunctional: glutathione-dependent formaldehyde dehydrogenase and alcohol dehydrogenase class III oxidoreductase protein AdhC1 or rsp0069 or rs02044 SWALL:Q8XTN7 (EMBL:AL646076) (368 aa) fasta scores: E(): 4e-128, 88.04% id in 368 aa; Upstream repeat region (ggcgc)3; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
   
 
 0.851
adhC
NADP-dependent alcohol dehydrogenase; Similar to Mycobacterium tuberculosis, and Mycobacterium bovis NADP-dependent alcohol dehydrogenase AdhC or Adh SWALL:ADH_MYCTU (SWALL:P31975) (346 aa) fasta scores: E(): 3.3e-68, 56% id in 350 aa, and to Xylella fastidiosa NADP-alcohol dehydrogenase XF1136 SWALL:Q9PE92 (EMBL:AE003949) (352 aa) fasta scores: E(): 3.9e-72, 58.48% id in 342 aa.
  
 
 0.753
BPSS1918
Putative alcohol dehydrogenase; Similar to Ralstonia solanacearum probable alcohol dehydrogenase-like oxidoreductase protein rsc1505 or rs03800 SWALL:Q8XZ99 (EMBL:AL646064) (334 aa) fasta scores: E(): 4.3e-81, 66.26% id in 329 aa, and to Bacillus stearothermophilus alcohol dehydrogenase SWALL:ADH3_BACST (SWALL:P42328) (339 aa) fasta scores: E(): 8.8e-32, 34.02% id in 338 aa.
  
 
 0.753
adhA
Similar to Rhizobium meliloti alcohol dehydrogenase AdhA or ra0704 or sma1296 SWALL:ADHA_RHIME (SWALL:O31186) (340 aa) fasta scores: E(): 3e-84, 64.37% id in 334 aa, and to Brucella melitensis alcohol dehydrogenase bmei1746 SWALL:Q8YEY1 (EMBL:AE009608) (373 aa) fasta scores: E(): 4.7e-95, 72.35% id in 340 aa.
  
 
 0.753
BPSL2358
Weakly similar to Clostridium pasteurianum pyruvate formate-lyase activating enzyme Act SWALL:PFLA_CLOPA (SWALL:Q46267) (238 aa) fasta scores: E(): 1e-05, 27.75% id in 209 aa. Similar to Pseudomonas aeruginosa probable radical-activating enzyme pa1919 SWALL:Q9I2I5 (EMBL:AE004618) (232 aa) fasta scores: E(): 3.2e-37, 50.21% id in 231 aa.
  
  
 0.680
BPSL2001
Putative thioesterase; Similar to Pseudomonas aeruginosa hypothetical protein pa5185 SWALL:Q9HU04 (EMBL:AE004931) (147 aa) fasta scores: E(): 1.6e-34, 60.95% id in 146 aa, and to Mycobacterium tuberculosis hypothetical protein rv0163 or mt0172 or mtci28.03 SWALL:O07408 (EMBL:Z97050) (151 aa) fasta scores: E(): 4.2e-22, 45.32% id in 139 aa.
 
   
 0.592
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
     
 0.522
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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