STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (243 aa)    
Predicted Functional Partners:
BPSL2566
Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
    0.991
BPSL2977
Similar to Escherichia coli exoribonuclease II Rnb or b1286 SWALL:RNB_ECOLI (SWALL:P30850) (644 aa) fasta scores: E(): 2e-08, 28.45% id in 355 aa, and to Neisseria meningitidis ribonuclease II-related protein nmb0282 SWALL:Q9K185 (EMBL:AE002385) (626 aa) fasta scores: E(): 2.2e-64, 39.9% id in 644 aa.
   
 0.970
rnr
Putative ribonuclease; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
   
 0.961
rpsA
30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
  
  0.847
BPSL2567
Putative coproporphyrinogen III oxidase family protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
     0.834
BPSL2187
Similar to Escherichia coli putative ATP-dependent RNA helicase RhlE or b0797 SWALL:RHLE_ECOLI (SWALL:P25888) (454 aa) fasta scores: E(): 1e-39, 43.29% id in 455 aa, and to Ralstonia solanacearum putative ATP-dependent RNA helicase protein rsc0952 or rs04426 SWALL:Q8Y0U1 (EMBL:AL646061) (608 aa) fasta scores: E(): 3.9e-74, 58.07% id in 458 aa. CDS is extended at the N-terminus in comparison to orthologues; Belongs to the DEAD box helicase family.
    
 0.823
rpsD
30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
  
 0.810
BPSL2324
Putative ATP-dependent helicase; Similar to C-terminal regions of Escherichia coli ATP-dependent helicase HrpA SWALL:HRPA_ECOLI (SWALL:P43329) (1300 aa) fasta scores: E(): 1.8e-126, 46.08% id in 1315 aa, and to Salmonella typhimurium helicase, ATP-dependent HrpA or stm1641 SWALL:Q8ZP95 (EMBL:AE008772) (1300 aa) fasta scores: E(): 7.2e-128, 46.3% id in 1313 aa. Poor translational start site, possible gene remnant.
    
 0.806
rpsK
30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.
  
 0.780
BPSL0130
Conserved hypothetical phage protein; Poor database matches. Similar to Ralstonia solanacearum hypothetical protein rsc0967 or rs04399 SWALL:Q8Y0S6 (EMBL:AL646062) (933 aa) fasta scores: E(): 6.5e-153, 50.53% id in 930 aa. N-terminus is similar to the N-termial region of Anabaena sp. DNA primase ALL323 SWALL:Q8YX92 (EMBL:AP003585) (640 aa) fasta scores: E(): 0.21, 23.27% id in 391 aa.
    
 
 0.773
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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