Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mtgAPutative peptidoglycan biosynthesis-related protein; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (256 aa)    
Predicted Functional Partners:
hemK
Protein methyltransferase HemK; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
     
 0.820
BPSL2977
Similar to Escherichia coli exoribonuclease II Rnb or b1286 SWALL:RNB_ECOLI (SWALL:P30850) (644 aa) fasta scores: E(): 2e-08, 28.45% id in 355 aa, and to Neisseria meningitidis ribonuclease II-related protein nmb0282 SWALL:Q9K185 (EMBL:AE002385) (626 aa) fasta scores: E(): 2.2e-64, 39.9% id in 644 aa.
       0.799
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
  
 0.771
mpl
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily.
 
   
 0.742
mltG
Putative lipoprotein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.
 
   
 0.703
mrdA
Penicillin-binding protein; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.
 
 
 
 0.696
BPSL0382
Putative membrane protein; Similar to Ralstonia solanacearum hypothetical transmembrane protein rsc0286 or rs03253 SWALL:Q8Y2P9 (EMBL:AL646058) (238 aa) fasta scores: E(): 3.5e-09, 40.9% id in 286 aa, and to Xanthomonas campestris hypothetical protein xcc3862 SWALL:AAM43093 (EMBL:AE012507) (286 aa) fasta scores: E(): 1.5e-06, 30.61% id in 294 aa.
   
 
 0.692
rodA
Rod shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
 
 
 
 0.656
BPSL2978
Similar to Ralstonia solanacearum hypothetical protein rsc2781 or rs00066 SWALL:Q8XVP9 (EMBL:AL646071) (210 aa) fasta scores: E(): 2.7e-47, 66.48% id in 188 aa, and to Vibrio cholerae hypothetical protein vc2432 SWALL:Q9KPD8 (EMBL:AE004313) (195 aa) fasta scores: E(): 2.9e-19, 38.5% id in 187 aa.
       0.644
spoT
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
 
   
 0.637
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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