STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa)    
Predicted Functional Partners:
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 0.999
putA
Bifunctional PutA protein [includes: proline dehydrogenase (EC 1.5.99.8) (proline oxidase); Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
    
 0.942
proC
Putative pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
 
 
 0.813
obg
Putative conserved GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
  
  
 0.759
hom
Similar to Pseudomonas aeruginosa homoserine dehydrogenase Hom or pa3736 SWALL:DHOM_PSEAE (SWALL:P29365) (434 aa) fasta scores: E(): 1e-98, 63.12% id in 442 aa, and to Ralstonia solanacearum probable homoserine dehydrogenase oxidoreductase protein rsc1327 or rs02849 SWALL:Q8XZR8 (EMBL:AL646064) (439 aa) fasta scores: E(): 8.2e-121, 78.73% id in 442 aa.
 
  
 0.636
cysM
Cysteine synthase; Similar to Escherichia coli cysteine synthase B CysM or b2421 SWALL:CYSM_ECOLI (SWALL:P16703) (303 aa) fasta scores: E(): 2.3e-65, 62.37% id in 295 aa and to Ralstonia solanacearum probable cysteine synthase B CysM or rsc0917 or rs04497 SWALL:Q8Y0X6 (EMBL:AL646061) (300 aa) fasta scores: E(): 8.8e-91, 82% id in 300 aa; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
   
 0.616
argA
Putative amino-acid acetyltransferase; Similar to Escherichia coli, and Escherichia coli O157:H7 amino-acid acetyltransferase ArgA SWALL:ARGA_ECOLI (SWALL:P08205) (443 aa) fasta scores: E(): 1.5e-76, 46.89% id in 435 aa, and to Ralstonia solanacearum probable amino-acid acetyltransferase protein rsc1250 or rs02762 SWALL:Q8XZZ5 (EMBL:AL646063) (451 aa) fasta scores: E(): 3.6e-123, 71.71% id in 449 aa. CDS is extended at the N-terminus in comparison to some orthologues. Possible alternative translational start site.
 
 
 
 0.596
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
  
  
 0.593
argB
Putative acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
 
 
 0.592
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
     
 0.591
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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