STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (245 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
   
 
 0.781
BPSL0191
Endonuclease/exonuclease/phosphatase family protein; Similar to the C-terminal region of Homo sapiens DNA repair major apurinic/ apyrimidinic endonuclease APEX or APE or HAP1 or REF1 or APX SWALL:APE1_HUMAN (SWALL:P27695) (317 aa) fasta scores: E(): 1.2e-32, 37.94% id in 253 aa, and to the full length Ralstonia solanacearum putative exodeoxyribonuclease III protein rsc0140 or rs01010 SWALL:Q8Y341 (EMBL:AL646057) (261 aa) fasta scores: E(): 5.7e-90, 79.45% id in 258 aa.
   
 0.758
BPSL2315
Endonuclease/exonuclease/phosphatase family protein; Similar to Ralstonia solanacearum probable exodeoxyribonuclease III protein rsc1593 or rs03955 SWALL:Q8XZ13 (EMBL:AL646065) (269 aa) fasta scores: E(): 1.7e-67, 67.79% id in 267 aa, and to Xanthomonas axonopodis exodeoxyribonuclease III xac4171 SWALL:AAM39006 (EMBL:AE012067) (259 aa) fasta scores: E(): 2e-54, 55.03% id in 258 aa.
   
 0.758
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
      0.718
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.688
trpC
Similar to Pseudomonas aeruginosa indole-3-glycerol phosphate synthase TrpC or Pa0651 SWALL:TRPC_PSEAE (SWALL:P20577) (278 aa) fasta scores: E(): 2.7e-56, 63.07% id in 260 aa; Belongs to the TrpC family.
       0.593
BPSL3054
Similar to Ralstonia solanacearum hypothetical protein Rsc2886 or Rs00215 SWALL:Q8XVE5 (EMBL:AL646072) (223 aa) fasta scores: E(): 2.3e-23, 46.33% id in 218 aa.
       0.576
tadA
Putative deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
 
 
 
 0.554
BPSL2556
Possible DNA polymerase/helicase; Similar to Bacillus halodurans DNA polymerase III PolC-type PolC or bh2418 SWALL:DPO3_BACHD (SWALL:Q9KA72) (1433 aa) fasta scores: E(): 1.1e-12, 35.54% id in 166 aa, and to Neisseria meningitidis DNA polymerase III, epsilon subunit nmb1451 SWALL:Q9JYS6 (EMBL:AE002495) (470 aa) fasta scores: E(): 2.2e-27, 42.35% id in 229 aa, and to Bacillus subtilis probable ATP-dependent helicase DinG homolog dinG SWALL:DING_BACSU (SWALL:P54394) (931 aa) fasta scores: E(): 7.6e-14, 38.79% id in 183 aa.
 
   
 0.552
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
 
 0.494
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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