Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
BPSS0803Similar to Bacillus cereus hemolysin III SWALL:HLY3_BACCE (SWALL:P54176) (219 aa) fasta scores: E(): 1.2e-31, 46.46% id in 198 aa, and to Neisseria meningitidis putative haemolysin nma1900 SWALL:Q9JTB2 (EMBL:AL162757) (208 aa) fasta scores: E(): 1.5e-45, 58.17% id in 208 aa. (211 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.618
BPSL0624
Putative protease; Similar to Pseudomonas aeruginosa staphylolytic protease preproenzyme LasA SWALL:P72166 (EMBL:U68175) (263 aa) fasta scores: E(): 1.5e-12, 39.43% id in 284 aa, and to Xanthomonas axonopodis hypothetical protein xac0112 SWALL:AAM35004 (EMBL:AE011634) (263 aa) fasta scores: E(): 8.4e-18, 45.55% id in 281 aa.
     
 0.600
bsaX
Surface presentation of antigens protein; Similar to Salmonella typhimurium, Salmonella typhi, Salmonella dublin, Salmonella enteritidis, Salmonella gallinarum, Salmonella senftenberg, and Salmonella typhisuis surface presentation of antigens protein SpaQ or stm2889 or sty3012 SWALL:SPAQ_SALTY (SWALL:P40704) (86 aa) fasta scores: E(): 3.7e-15, 54.21% id in 83 aa, and to Yersinia enterocolitica YsaS SWALL:Q93NK6 (EMBL:AF369954) (89 aa) fasta scores: E(): 7.6e-18, 65.06% id in 83 aa.
      
 0.553
fliH
Similar to Salmonella typhimurium flagellar assembly protein FliH SWALL:FLIH_SALTY (SWALL:P15934) (235 aa) fasta scores: E(): 4.3e-16, 34.22% id in 225 aa, and to Burkholderia cepacia putative FliI inhibitor FliH SWALL:Q8VQP5 (EMBL:AF453480) (227 aa) fasta scores: E(): 3.4e-58, 78.85% id in 227 aa.
      
 0.518
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.518
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
    0.440
mprA
Serine metalloprotease precursor; Previously sequenced as Burkholderia pseudomallei serine metalloprotease precursor SWALL:Q9F881 (EMBL:AF254803) (500 aa) fasta scores: E(): 7.7e-170, 100% id in 500 aa. Similar to Xanthomonas campestris extracellular protease precursor xcc0851 SWALL:EXPR_XANCP (SWALL:P23314) (580 aa) fasta scores: E(): 4.5e-65, 49.02% id in 463 aa.
      
 0.435
ribD
Multifunctional riboflavin biosynthetic protein [deaminase, reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.416
BPSS1125
Putative riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.416
gcvP
Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
       0.406
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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