STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdlBSimilar to Pseudomonas putida L(+)-mandelate dehydrogenase MdlB SWALL:MDLB_PSEPU (SWALL:P20932) (393 aa) fasta scores: E(): 5.7e-46, 38.36% id in 378 aa, and to Brucella melitensis L-lactate dehydrogenase bmeii0377 SWALL:Q8YD00 (EMBL:AE009675) (382 aa) fasta scores: E(): 4.5e-42, 35.67% id in 370 aa. CDS is extended at the N-terminus in comparison to orthologues. (407 aa)    
Predicted Functional Partners:
BPSL2842
Putative FAD-binding oxidase; Similar to Escherichia coli, and Escherichia coli O6 glycolate oxidase subunit GlcD or Gox or b2979 or c3709 SWALL:GLCD_ECOLI (SWALL:P52075) (499 aa) fasta scores: E(): 1.3e-37, 32.22% id in 419 aa, and to the C-terminal region of Saccharomyces cerevisiae D-lactate dehydrogenase [cytochrome], mitochondrial precursor Dld1 or Dld or ydl174C SWALL:DLD1_YEAST (SWALL:P32891) (587 aa) fasta scores: E(): 1.6e-60, 43.34% id in 436 aa.
 
 0.939
BPSS1318
Similar to Saccharomyces cerevisiae D-lactate dehydrogenase [cytochrome], mitochondrial precursor DlD1 or Dld or ydl174C SWALL:DLD1_YEAST (SWALL:P32891) (587 aa) fasta scores: E(): 1.6e-53, 37.01% id in 489 aa, and to Ralstonia solanacearum putative D-lactate dehydrogenase Dld or rsc2664 or rs04542 SWALL:Q8XW11 (EMBL:AL646071) (472 aa) fasta scores: E(): 1.1e-101, 58.98% id in 451 aa, and to Rhizobium loti probable D-lactate dehydrogenase mll1488 SWALL:Q98KG4 (EMBL:AP002997) (575 aa) fasta scores: E(): 2.4e-99, 56.4% id in 445 aa. Possible alternative translational start.
 
 0.938
maeB
Similar to Escherichia coli NADP-dependent malic enzyme MaeB or b2463 SWALL:MAO2_ECOLI (SWALL:P76558) (759 aa) fasta scores: E(): 5.4e-181, 61.8% id in 754 aa, and to Ralstonia solanacearum putative NADP-dependent malic enzyme oxidoreductase protein rsc2767 or rs00080 SWALL:Q8XVR2 (EMBL:AL646071) (781 aa) fasta scores: E(): 0, 78.28% id in 760 aa.
    
 0.933
BPSL3242
Similar to Escherichia coli NADP-dependent malic enzyme MaeB or b2463 SWALL:MAO2_ECOLI (SWALL:P76558) (759 aa) fasta scores: E(): 1.6e-184, 63.72% id in 758 aa, and to Ralstonia solanacearum putative NADP-dependent malic enzyme oxidoreductase protein MaeB1 or Rsc2123 or Rs03232 SWALL:Q8XXJ0 (EMBL:AL646068) (773 aa) fasta scores: E(): 5.7e-194, 67.86% id in 753 aa; Belongs to the malic enzymes family.
    
 0.933
pykA
Putative pyruvate kinase II protein; Similar to Pseudomonas hydrogenothermophila pyruvate kinase Pyk SWALL:Q9LBF0 (EMBL:AB042618) (473 aa) fasta scores: E(): 5.5e-91, 58.82% id in 476 aa, and to Ralstonia solanacearum probable pyruvate kinase II protein rsc0572 or rs04893 SWALL:Q8Y1W5 (EMBL:AL646060) (479 aa) fasta scores: E(): 2.9e-131, 78.49% id in 479 aa.
   
 0.923
pyk
Pyruvate kinase; Similar to Bacillus stearothermophilus pyruvate kinase Pyk SWALL:KPYK_BACST (SWALL:Q02499) (587 aa) fasta scores: E(): 1.7e-60, 41.27% id in 470 aa, and to Pseudomonas aeruginosa pyruvate kinase I PykF or pa1498 SWALL:Q9I3L4 (EMBL:AE004578) (477 aa) fasta scores: E(): 1.5e-83, 55.57% id in 466 aa.
   
 0.923
ldhA
Similar to Escherichia coli D-lactate dehydrogenase LdhA or HslI or HtpH or b1380 SWALL:LDHD_ECOLI (SWALL:P52643) (329 aa) fasta scores: E(): 3.3e-60, 51.81% id in 330 aa and to Pseudomonas aeruginosa D-lactate dehydrogenase LdhA or pa0927 SWALL:Q9I530 (EMBL:AE004527) (329 aa) fasta scores: E(): 2.8e-86, 70.6% id in 330 aa; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.918
lldA
Similar to Neisseria meningitidis L-lactate dehydrogenase LldA or nma1592 SWALL:Q9JTX1 (EMBL:AL162756) (390 aa) fasta scores: E(): 8.4e-92, 61.93% id in 373 aa, and to Pseudomonas aeruginosa L-lactate dehydrogenase LldA or pa2382 SWALL:Q9I197 (EMBL:AE004664) (383 aa) fasta scores: E(): 1.4e-103, 72.41% id in 377 aa, and to Agrobacterium tumefaciens L-lactate dehydrogenase LldA or atu2318 or agr_c_4216 SWALL:Q8UD10 (EMBL:AE009181) (382 aa) fasta scores: E(): 3.7e-94, 64.17% id in 374 aa.
  
  
 
0.916
BPSL0724
Putative thiamine pyrophosphate requiring enzyme; Similar to Pseudomonas aeruginosa probable decarboxylase pa2108 SWALL:Q9I207 (EMBL:AE004638) (590 aa) fasta scores: E(): 6.6e-132, 56.99% id in 593 aa, and to Streptomyces coelicolor putative pyruvate dehydrogenase sco7412 or sc6d11.08 SWALL:Q9L147 (EMBL:AL158061) (600 aa) fasta scores: E(): 2.2e-130, 55.48% id in 593 aa, and to Rhizobium meliloti putative pyruvate oxidase protein rb0095 or smb20095 SWALL:Q92X67 (EMBL:AL603642) (605 aa) fasta scores: E(): 6.3e-69, 40.85% id in 607 aa, and to Methanopyrus kandleri acetolactate synthase, [...]
  
 
 0.914
poxB
Similar to Escherichia coli pyruvate dehydrogenase [cytochrome] PoxB or b0871 SWALL:POXB_ECOLI (SWALL:P07003) (572 aa) fasta scores: E(): 5.4e-146, 64.44% id in 571 aa, and to Xanthomonas axonopodis pyruvate dehydrogenase PoxB or xac0224 SWALL:AAM35116 (EMBL:AE011647) (575 aa) fasta scores: E(): 9.1e-152, 66.66% id in 570 aa; Belongs to the TPP enzyme family.
  
 
 0.914
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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