STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (405 aa)    
Predicted Functional Partners:
metXS
Putative homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
 
  
 0.973
BPSL1716
Similar to Rhizobium loti cysteine synthase mll9227 SWALL:Q981U9 (EMBL:AP003015) (351 aa) fasta scores: E(): 4.2e-53, 45.74% id in 341 aa, and to Alcaligenes eutrophus cysteine synthase CysM SWALL:CYSM_ALCEU (SWALL:Q44004) (339 aa) fasta scores: E(): 9.2e-16, 31.35% id in 303 aa.
 
 0.969
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.967
metH2
Similar to Ralstonia solanacearum probable 5-methyltetrahydrofolate--homocysteine methyltransferase rsc0295 or rs03262 SWALL:Q8Y2P0 (EMBL:AL646058) (346 aa) fasta scores: E(): 2.9e-107, 80.29% id in 345 aa, and to the N-terminal region Escherichia coli 5-methyltetrahydrofolate--homocysteine methyltransferase MetH SWALL:METH_ECOLI (SWALL:P13009) (1226 aa) fasta scores: E(): 3.2e-72, 59.07% id in 325 aa. BPSL0385 and BPSL03856 are similar to the N- and C-terminal regions of many 5-methyltetrahydrofolate--homocysteine methyltransferases. In some organisms these two domains are also found [...]
  
 
 0.947
BPSS0190
Putative AraC-family transcriptional regulator (fragment); Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 16.0, E-value 0.049.
 
 
0.936
cysI
Similar to Pseudomonas aeruginosa sulfite reductase CysI SWALL:O31037 (EMBL:AF026066) (552 aa) fasta scores: E(): 9.2e-145, 64.91% id in 553 aa, and to Ralstonia solanacearum probable sulfite reductase oxidoreductase protein CysI1 or rsc2425 or rs02684 SWALL:Q8XWP8 (EMBL:AL646070) (553 aa) fasta scores: E(): 3.4e-169, 73.65% id in 558 aa, and to Pseudomonas aeruginosa sulfite reductase CysI or pa1838 SWALL:Q9I2Q7 (EMBL:AE004609) (552 aa) fasta scores: E(): 9.9e-152, 67.26% id in 553 aa; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
 0.934
BPSL1319
Putative nitrite/sulfite reductase; Similar to Ralstonia solanacearum probable sulfite reductase oxidoreductase protein CysI2 or rsc1862 or rs03422 SWALL:Q8XYA0 (EMBL:AL646067) (577 aa) fasta scores: E(): 4.4e-50, 51.78% id in 616 aa, and to Phormidium laminosum ferredoxin--nitrite reductase NirA or Nir SWALL:NIR_PHOLA (SWALL:Q51879) (510 aa) fasta scores: E(): 6.6e-10, 26.8% id in 567 aa. Note: The region between residues 80 and 105 presents very low or none similarities with the database matches.
 
 0.934
metH1
Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.927
BPSL1542
Similar to Escherichia coli cystathionine beta-lyase MetC or b3008 SWALL:METC_ECOLI (SWALL:P06721) (395 aa) fasta scores: E(): 5.8e-47, 37.84% id in 362 aa, and to Ralstonia solanacearum putative cystathionine beta-lyase rsc1639 or rs04013 SWALL:Q8XYW7 (EMBL:AL646065) (404 aa) fasta scores: E(): 3.2e-94, 64.43% id in 388 aa.
  
  
 
0.926
BPSS1241
Putative bifunctional reductase; Possible fusion protein. N-terminal region is similar to Synechococcus sp. nitrate reductase NarB SWALL:NARB_SYNP7 (SWALL:P39458) (729 aa) fasta scores: E(): 9.4e-73, 43.09% id in 724 aa. C-terminal region is similar to Escherichia coli sulfite reductase [NADPH] flavoprotein alpha-component CysJ SWALL:CYSJ_ECOLI (SWALL:P38038) (598 aa) fasta scores: E(): 8.1e-70, 39.13% id in 598 aa; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
  
 0.926
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.