STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mhpFAcetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (297 aa)    
Predicted Functional Partners:
mhpE
4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 0.999
leuA-2
hydroxymethylglutaryl-CoA lyase-like protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 0.985
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 0.985
hpcG
Similar to Escherichia coli 2-oxo-hepta-3-ene-1,7-dioic acid hydratase HpcG SWALL:HPCG_ECOLI (SWALL:P42270) (264 aa) fasta scores: E(): 3.3e-74, 70.3% id in 266 aa, and to Salmonella typhimurium, and Salmonella typhi 4-hydroxyphenylacetate catabolism stm1105 or sty1139 SWALL:Q8XGD0 (EMBL:AE008748) (267 aa) fasta scores: E(): 1.4e-80, 74.06% id in 266 aa.
 
  
 0.929
BPSS0514
acetyl-CoA hydrolase/transferase; Similar to Clostridium kluyveri succinyl-CoA:coenzyme A transferase Cat1 SWALL:CAT1_CLOKL (SWALL:P38946) (538 aa) fasta scores: E(): 2e-97, 51.73% id in 520 aa, and to Xanthomonas campestris coa tranferase xcc3588 SWALL:Q8P4W8 (EMBL:AE012479) (504 aa) fasta scores: E(): 1.2e-133, 68.52% id in 502 aa. Possible alternative translational start sites.
  
  
  0.911
BPSS1955
Putative phosphate acetyltransferase/enoyl-CoA hydratase fusion protein; N-terminal region similar to Pseudomonas aeruginosa (R)-specific enoyl-CoA hydratase PhaJ1 or pa3302 SWALL:Q9LBK2 (EMBL:AB040025) (156 aa) fasta scores: E(): 1.1e-17, 44.44% id in 153 aa, and C-terminal region to Rhizobium meliloti phosphate acetyltransferase Pta SWALL:PTA_RHIME (SWALL:Q9X448) (316 aa) fasta scores: E(): 5.4e-55, 57.37% id in 305 aa.
    
 0.909
accB
Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
     
 0.908
BPSL1020
Similar to Escherichia coli putative aldehyde dehydrogenase AldH or b1300 SWALL:DHAL_ECOLI (SWALL:P23883) (495 aa) fasta scores: E(): 2.3e-61, 41.12% id in 479 aa, and to Ralstonia solanacearum probable aldehyde dehydrogenase oxidoreductase protein rsc2350 or rs01196 SWALL:Q8XWX0 (EMBL:AL646069) (478 aa) fasta scores: E(): 5.1e-138, 73.31% id in 476 aa.
    
 0.905
BPSL1380
Putative acetyl-CoA synthetase; Similar to Bacillus subtilis acetyl-coenzyme A synthetase AcsA SWALL:ACSA_BACSU (SWALL:P39062) (572 aa) fasta scores: E(): 5.7e-54, 34.63% id in 540 aa, and to Rhizobium loti acetyl-CoA synthetase mll6017 SWALL:Q98AG0 (EMBL:AP003008) (562 aa) fasta scores: E(): 8.3e-119, 55.51% id in 553 aa.
     
 0.905
BPSL1550
Similar to Bacillus subtilis betaine aldehyde dehydrogenase GbsA SWALL:DHAB_BACSU (SWALL:P71016) (490 aa) fasta scores: E(): 1.9e-59, 40.33% id in 476 aa, and to Ralstonia solanacearum putative betaine aldehyde dehydrogenase rsc1456 or rs03851 SWALL:Q8XZE5 (EMBL:AL646064) (478 aa) fasta scores: E(): 1.1e-127, 71.3% id in 474 aa.
    
 0.905
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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