STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cyoC-2Cytochrome O ubiquinol oxidase subunit III; Similar to Escherichia coli, Escherichia coli O6, and Shigella flexneri cytochrome O ubiquinol oxidase subunit III CyoC or b0430 or c0541 or sf0371 SWALL:CYOC_ECOLI (SWALL:P18402) (204 aa) fasta scores: E(): 1.1e-41, 53.6% id in 194 aa, and to Pseudomonas putida cytochrome O ubiquinol oxidase subunit III CyoC SWALL:CYOC_PSEPU (SWALL:Q9WWR3) (207 aa) fasta scores: E(): 5.3e-44, 55.72% id in 192 aa. (197 aa)    
Predicted Functional Partners:
BPSL0723
Similar to Bacillus firmus cytochrome c oxidase polypeptide II precursor ctaC SWALL:COX2_BACFI (SWALL:Q04441) (342 aa) fasta scores: E(): 3e-28, 34.07% id in 314 aa, and to Rhizobium loti cytochrome oxidase subunit II mll9631 SWALL:Q98P34 (EMBL:AP003017) (330 aa) fasta scores: E(): 1.6e-39, 43.77% id in 297 aa, and to Rhizobium meliloti putative cytochrome c oxidase chain II protein rb0946 or smb21368 SWALL:Q92UY8 (EMBL:AL603645) (327 aa) fasta scores: E(): 2e-35, 40.36% id in 327 aa; Possible alternative start at codon 70.
 
 0.996
cyoA-2
Similar to Escherichia coli, and Escherichia coli O6 ubiquinol oxidase polypeptide II precursor CyoA or b0432 or c0543 SWALL:CYOA_ECOLI (SWALL:P18400) (315 aa) fasta scores: E(): 6e-66, 55.9% id in 288 aa, and to Acetobacter aceti ubiquinol oxidase polypeptide II precursor CyaB SWALL:QOX2_ACEAC (SWALL:P50653) (307 aa) fasta scores: E(): 7.3e-73, 63.76% id in 287 aa.
 
 0.994
BPSL0453
Putative cytochrome c oxidase; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
  
 0.993
cyoD-2
Cytochrome O ubiquinol oxidase protein; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri cytochrome O ubiquinol oxidase protein CyoD or b0429 or z0532 or ecs0483 or sf0370 SWALL:CYOD_ECOLI (SWALL:P18403) (109 aa) fasta scores: E(): 2.7e-16, 49.5% id in 101 aa, and to Pseudomonas putida cytochrome O ubiquinol oxidase protein CyoD SWALL:CYOD_PSEPU (SWALL:Q9WWR4) (110 aa) fasta scores: E(): 2.7e-15, 42.72% id in 110 aa.
 
 
 0.992
cyoB-2
Ubiquinol oxidase polypeptide I; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 ubiquinol oxidase polypeptide I CyoB or b0431 or c0542 or z0534 or ecs0485 SWALL:CYOB_ECOLI (SWALL:P18401) (663 aa) fasta scores: E(): 1.5e-189, 67.22% id in 653 aa, and to Acetobacter aceti ubiquinol oxidase polypeptide I precursor CyaA SWALL:QOX1_ACEAC (SWALL:P98009) (664 aa) fasta scores: E(): 4.4e-197, 69.06% id in 666 aa; Belongs to the heme-copper respiratory oxidase family.
 0.989
cyoA
Similar to Escherichia coli ubiquinol oxidase polypeptide II precursor CyoA SWALL:CYOA_ECOLI (SWALL:P18400) (315 aa) fasta scores: E(): 2.9e-63, 55.51% id in 290 aa, and to Acetobacter pasteurianus ubiquinol oxidase subunit II SWALL:BAB97173 (EMBL:AB086015) (308 aa) fasta scores: E(): 1.2e-72, 66.07% id in 280 aa. Similar to BPSS1897, 93.220% identity (93.537% ungapped) in 295 aa overlap.
 
 0.978
cyoD
Similar to Escherichia coli, and Escherichia coli O157:H7 cytochrome o ubiquinol oxidase protein CyoD SWALL:CYOD_ECOLI (SWALL:P18403) (109 aa) fasta scores: E(): 4.5e-16, 46.29% id in 108 aa, and to Yersinia pestis cytochrome o ubiquinol oxidase subunit ypo3167 SWALL:Q8ZC55 (EMBL:AJ414155) (110 aa) fasta scores: E(): 2.3e-18, 50% id in 108 aa. Similar to BPSS1894, 80.000% identity (80.000% ungapped) in 110 aa overlap.
 
 
 0.968
cyoB
Ubiquinol oxidase polypeptide I; Similar to Escherichia coli, and Escherichia coli O157:H7 ubiquinol oxidase polypeptide I CyoB SWALL:CYOB_ECOLI (SWALL:P18401) (663 aa) fasta scores: E(): 6.3e-183, 66.2% id in 651 aa, and to Acetobacter pasteurianus ubiquinol oxidase subunit I SWALL:BAB97174 (EMBL:AB086015) (663 aa) fasta scores: E(): 4.4e-195, 69.38% id in 650 aa. Similar to BPSS1896, 84.179% identity (84.431% ungapped) in 670 aa overlap; Belongs to the heme-copper respiratory oxidase family.
 0.958
nuoH
NADH dehydrogenase I chain H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
   
 0.938
nuoM
Similar to Rickettsia prowazekii NADH dehydrogenase I chain M rp793 SWALL:NUOM_RICPR (SWALL:Q9ZCG0) (491 aa) fasta scores: E(): 5.8e-86, 48.15% id in 488 aa, and to Neisseria meningitidis NADH dehydrogenase chain M nma2229 SWALL:Q9JSL7 (EMBL:AL162758) (498 aa) fasta scores: E(): 5.4e-122, 66.46% id in 498 aa.
   
 0.938
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.