node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carA | carB | CA_C2645 | CA_C2644 | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | Carbamoylphosphate synthase large subunit. | 0.999 |
carA | pyrB | CA_C2645 | CA_C2654 | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
carA | pyrC | CA_C2645 | CA_C0519 | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.995 |
carA | pyrD | CA_C2645 | CA_C2650 | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. | 0.953 |
carA | pyrE | CA_C2645 | CA_C0027 | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | Orotate phosphoribosyltranspherase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.928 |
carA | pyrF | CA_C2645 | CA_C2652 | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.944 |
carA | pyrI | CA_C2645 | CA_C2653 | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.962 |
carA | pyrR | CA_C2645 | CA_C2113 | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | Uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.827 |
carA | pyrZ | CA_C2645 | CA_C2651 | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.838 |
carA | uraA | CA_C2645 | CA_C2112 | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | Uracil permease UraA/PyrP. | 0.873 |
carB | carA | CA_C2644 | CA_C2645 | Carbamoylphosphate synthase large subunit. | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | 0.999 |
carB | pyrB | CA_C2644 | CA_C2654 | Carbamoylphosphate synthase large subunit. | Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
carB | pyrC | CA_C2644 | CA_C0519 | Carbamoylphosphate synthase large subunit. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.996 |
carB | pyrD | CA_C2644 | CA_C2650 | Carbamoylphosphate synthase large subunit. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. | 0.975 |
carB | pyrE | CA_C2644 | CA_C0027 | Carbamoylphosphate synthase large subunit. | Orotate phosphoribosyltranspherase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.947 |
carB | pyrF | CA_C2644 | CA_C2652 | Carbamoylphosphate synthase large subunit. | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.881 |
carB | pyrI | CA_C2644 | CA_C2653 | Carbamoylphosphate synthase large subunit. | Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.962 |
carB | pyrR | CA_C2644 | CA_C2113 | Carbamoylphosphate synthase large subunit. | Uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.925 |
carB | pyrZ | CA_C2644 | CA_C2651 | Carbamoylphosphate synthase large subunit. | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.828 |
carB | uraA | CA_C2644 | CA_C2112 | Carbamoylphosphate synthase large subunit. | Uracil permease UraA/PyrP. | 0.861 |