STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
larCUncharacterized conserved protein; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (420 aa)    
Predicted Functional Partners:
CA_C0775
ATP-utilizing enzyme of the PP-loop superfamily.
  
 0.985
CA_C0776
NCAIR mutase (PurE)-related protein.
 
  
 0.981
CA_C0771
Cobalamin biosynthesis protein CbiM.
 
    0.892
CA_C0772
Cobalt permease.
 
    0.829
CA_C0773
ABC-type cobalt transport protein ATPase component; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
  
    0.813
CA_C0769
Uncharacterized conserved protein.
 
  
 0.790
CA_C0777
Acetyltransferase (the isoleucine patch superfamily).
  
    0.469
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
       0.446
cinA
Competence-damage inducible protein, CINA; Belongs to the CinA family.
       0.446
CA_C0765
Fe-S oxidoreductase.
 
    0.444
Your Current Organism:
Clostridium acetobutylicum
NCBI taxonomy Id: 272562
Other names: C. acetobutylicum ATCC 824, Clostridium acetobutylicum ATCC 824, Clostridium acetobutylicum DSM 792, Clostridium acetobutylicum str. ATCC 824, Clostridium acetobutylicum strain ATCC 824
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.