STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
fliDFlagellar hook-associated protein 2 FliD (or HAP2); Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (507 aa)    
Predicted Functional Partners:
flgL
Flagellar hook-associated protein FlgL (or HAP3).
 
 
 0.995
flgK
Flagellar hook-associated protein FlgK (or HAP1).
 
  
 0.993
fliS2
Flagellar protein FliS2.
 
 
 0.991
fliS1
Flagellar protein FliS1.
 
 
 0.990
fliC
Flagellin C; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
 
 
 0.990
fliW
Flagellar assembly factor FliW; Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
 
  
 0.984
fliI
ATP synthase subunit beta FliI; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651.
 
  
 0.978
flgB
Flagellar basal-body rod protein FlgB; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651.
 
  
 0.976
fliM
Flagellar motor switch protein FliM.
 
  
 0.976
fliH
Flagellar assembly protein FliH; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651.
 
  
 0.971
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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