STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CdeCExosporium cysteine rich protein; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (405 aa)    
Predicted Functional Partners:
bclA1
Putative exosporium glycoprotein; Experimentally verified as part of mature spore proteome PMID:19542279.
   
  
 0.634
bclA3
Exosporium glycoprotein BclA3.
   
  
 0.634
cotE
Spore coat protein: peroxiredoxin/chitinase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
   
  
 0.631
bclA2
Putative exosporium glycoprotein.
   
  
 0.629
sleC
Spore cortex-lytic enzyme pre-pro-form; Experimentally verified as part of mature spore proteome PMID:19542279.
   
  
 0.613
cotB
Spore coat protein; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279.
   
  
 0.613
spoIVA
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat and is required for proper coat localization to the forespore.
   
  
 0.514
cotCB
Spore-coat protein, manganese catalase; Experimentally verified as part of mature spore proteome PMID:19542279.
   
  
 0.510
sigK
Sigma K; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
      
 0.507
cotD
Spore coat protein, manganese catalase; Experimentally verified as part of mature spore proteome PMID:19542279.
   
  
 0.475
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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