CAJ67918.1 protein (Clostridioides difficile)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

CAJ67918.1

PTS system, mannose/fructose/sorbose IIA component. (136 aa)

Predicted Functional Partners:

CAJ67920.1

0.997

CAJ67921.1

0.997

CAJ67922.1

0.997

CAJ67323.1

0.990

xynD

0.990

xynC

0.990

CAJ70174.1

0.990

xynB

0.987

CAJ67106.1

0.960

ptsH

0.949

Your Current Organism:

Clostridioides difficile

NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAJ67106.1	CAJ67323.1	CD630_02840	CD630_04940	PTS system, mannose/fructose/sorbose IIA component.	PTS system, mannose/fructose/sorbose IID component.	0.990
CAJ67106.1	CAJ67918.1	CD630_02840	CD630_10740	PTS system, mannose/fructose/sorbose IIA component.	PTS system, mannose/fructose/sorbose IIA component.	0.960
CAJ67106.1	CAJ67920.1	CD630_02840	CD630_10760	PTS system, mannose/fructose/sorbose IIA component.	PTS system, mannose/fructose/sorbose IIB component.	0.877
CAJ67106.1	CAJ67921.1	CD630_02840	CD630_10770	PTS system, mannose/fructose/sorbose IIA component.	PTS system, mannose/fructose/sorbose IIC component.	0.878
CAJ67106.1	CAJ67922.1	CD630_02840	CD630_10780	PTS system, mannose/fructose/sorbose IIA component.	PTS system, mannose/fructose/sorbose IID component.	0.895
CAJ67106.1	CAJ70174.1	CD630_02840	CD630_32770	PTS system, mannose/fructose/sorbose IIA component.	PTS system, mannose/fructose/sorbose IIC component.	0.988
CAJ67106.1	ptsH	CD630_02840	CD630_27560	PTS system, mannose/fructose/sorbose IIA component.	PTS system, HPr protein.	0.966
CAJ67106.1	xynB	CD630_02840	CD630_30680	PTS system, mannose/fructose/sorbose IIA component.	PTS system, xyloside-specific IIB component.	0.987
CAJ67106.1	xynC	CD630_02840	CD630_30700	PTS system, mannose/fructose/sorbose IIA component.	PTS system, xyloside-specific IIC component.	0.986
CAJ67106.1	xynD	CD630_02840	CD630_30690	PTS system, mannose/fructose/sorbose IIA component.	PTS system, xyloside-specific IID component.	0.988
CAJ67323.1	CAJ67106.1	CD630_04940	CD630_02840	PTS system, mannose/fructose/sorbose IID component.	PTS system, mannose/fructose/sorbose IIA component.	0.990
CAJ67323.1	CAJ67918.1	CD630_04940	CD630_10740	PTS system, mannose/fructose/sorbose IID component.	PTS system, mannose/fructose/sorbose IIA component.	0.990
CAJ67323.1	CAJ67920.1	CD630_04940	CD630_10760	PTS system, mannose/fructose/sorbose IID component.	PTS system, mannose/fructose/sorbose IIB component.	0.907
CAJ67323.1	CAJ67921.1	CD630_04940	CD630_10770	PTS system, mannose/fructose/sorbose IID component.	PTS system, mannose/fructose/sorbose IIC component.	0.984
CAJ67323.1	CAJ70174.1	CD630_04940	CD630_32770	PTS system, mannose/fructose/sorbose IID component.	PTS system, mannose/fructose/sorbose IIC component.	0.999
CAJ67323.1	ptsH	CD630_04940	CD630_27560	PTS system, mannose/fructose/sorbose IID component.	PTS system, HPr protein.	0.914
CAJ67323.1	xynB	CD630_04940	CD630_30680	PTS system, mannose/fructose/sorbose IID component.	PTS system, xyloside-specific IIB component.	0.990
CAJ67323.1	xynC	CD630_04940	CD630_30700	PTS system, mannose/fructose/sorbose IID component.	PTS system, xyloside-specific IIC component.	0.998
CAJ67323.1	xynD	CD630_04940	CD630_30690	PTS system, mannose/fructose/sorbose IID component.	PTS system, xyloside-specific IID component.	0.916
CAJ67918.1	CAJ67106.1	CD630_10740	CD630_02840	PTS system, mannose/fructose/sorbose IIA component.	PTS system, mannose/fructose/sorbose IIA component.	0.960

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Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.923

expected number of edges:

13

PPI enrichment p-value:

0.162

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006707

Cholesterol catabolic process

3 of 11

2.4

1.75

0.00053

GO:0006629

Lipid metabolic process

6 of 437

1.11

0.99

0.00055

GO:0006633

Fatty acid biosynthetic process

3 of 103

1.43

0.77

0.0220

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

3 of 29

1.98

1.22

0.0044

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

3 of 35

1.9

1.2

0.0044

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9435

Mixed, incl. GMC oxidoreductase, and Oxygen oxidoreductase covalent FAD-binding site

3 of 6

2.67

2.04

0.00018

CL:2969

Mixed, incl. DUF35 OB-fold domain, acyl-CoA-associated, and Thiolase

3 of 10

2.44

1.89

0.00030

CL:3441

ACP-like superfamily, and MbtH-like domain

3 of 55

1.7

1.09

0.0057

CL:3450

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group., and Male sterility protein

2 of 11

2.23

1.07

0.0103

CL:3430

Mixed, incl. ACP-like superfamily, and Cytochrome P450

4 of 163

1.36

0.96

0.0053

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

kphy00984

Steroid degradation

3 of 17

2.21

2.0

0.00014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034081

Polyketide synthase complex

3 of 28

2.0

1.46

0.0014

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0001

2Fe-2S

2 of 9

2.31

1.14

0.0076

KW-0596

Phosphopantetheine

3 of 59

1.67

1.03

0.0076

KW-0408

Iron

3 of 160

1.24

0.6

0.0449

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00975

Thioesterase domain

3 of 9

2.49

1.98

0.00021

PF05199

GMC oxidoreductase

2 of 9

2.31

0.83

0.0295

PF00111

2Fe-2S iron-sulfur cluster binding domain

2 of 11

2.23

0.83

0.0295

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001031

Thioesterase

3 of 12

2.37

1.61

0.0010

IPR006162

Phosphopantetheine attachment site

3 of 29

1.98

1.17

0.0056

IPR020806

Polyketide synthase, phosphopantetheine-binding domain

3 of 35

1.9

1.12

0.0064

IPR007867

Glucose-methanol-choline oxidoreductase, C-terminal

2 of 9

2.31

0.88

0.0239

IPR000172

Glucose-methanol-choline oxidoreductase, N-terminal

2 of 9

2.31

0.88

0.0239

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00823

Phosphopantetheine attachment site

3 of 20

2.14

1.81

0.00031

SM00826

PKS_DH

2 of 11

2.23

1.13

0.0078

SM00825

Beta-ketoacyl synthase

2 of 12

2.19

1.13

0.0078

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 14

2.12

1.12

0.0078

SM00827

Acyl transferase domain in polyketide synthase (PKS) enzymes.

2 of 15

2.09

1.11

0.0078

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