STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pflDFormate acetyltransferase (Pyruvate formate-lyase). (790 aa)    
Predicted Functional Partners:
pflC
Pyruvate formate-lyase 2-activating enzyme.
  
 0.978
pflE
Pyruvate formate-lyase (activating enzyme); Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651.
  
 0.913
hpdA
Putative 4-hydroxyphenylacetate decarboxylase,activating subunit HpdA; Activation of 4-hydroxyphenylacetate decarboxylase under anaerobic conditions by generation of an organic free radical.
  
 0.905
pflA
Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.
  
 0.870
hpdC
Putative 4-hydroxyphenylacetate decarboxylase,regulatory subunit HpdC; Decarboxylates phenylacetates with a hydroxyl group in the p- position. Active toward 4-hydroxyphenylacetate, 3,4- dihydroxyphenylacetate and p-hydroxymandelate, forming 4-methylphenol, 4-methylcatechol and p-hydroxybenzylalcohol respectively (By similarity).
  
   0.738
adhE
Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 
 0.733
adhE1
Aldehyde-alcohol dehydrogenase; Experimentally verified as part of mature spore proteome PMID:19542279; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 
 0.733
pfo
Pyruvate-ferredoxin oxidoreductase; Experimentally verified as part of mature spore proteome PMID:19542279.
    
 0.724
CAJ67972.1
Transcriptional regulator, RmlC-type.
  
    0.681
cutC
Copper homeostasis protein; Participates in the control of copper homeostasis. Belongs to the CutC family.
   
  
 0.640
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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