STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAJ68845.1Putative enzyme, cyclase family. (210 aa)    
Predicted Functional Partners:
pycA
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
     
 0.816
YtsJ
Putative NAD-dependent malic enzyme.
   
 
  0.807
fumA
Fumarate hydratase class I, subunit A.
  
 
  0.805
fumB
Fumarate hydratase class I, subunit B.
   
 
  0.803
plfB
Formate acetyltransferase (Pyruvate formate-lyase); Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279.
     
  0.800
CAJ68844.1
Putative oligonucleotide binding regulator.
  
    0.710
CAJ68843.1
Putative membrane protein.
 
    0.626
CAJ68359.2
Transcriptional regulator, HTH-type; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651.
  
    0.556
CAJ68530.1
Transcriptional regulator, RmlC-type.
  
    0.556
CAJ68846.2
Putative protein, Sir2 family; putative silencing, chromosome stability or ageing; putative ADP ribosyltransferase.
       0.542
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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