STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (404 aa)    
Predicted Functional Partners:
pyk
Pyruvate kinase (PK); Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the pyruvate kinase family.
  
 
 0.999
pgi
Glucose-6-phosphate isomerase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the GPI family.
  
 0.988
GatY2
Putative fructose-1-6-bisphosphate aldolase.
  
 
 0.936
pfkA
6-phosphofructokinase (Phosphofructokinase) (Phosphohexokinase); Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  
  
0.934
GatY1
Tagatose-bisphosphate aldolase.
  
 
 0.933
fba
Fructose-1,6-bisphosphate aldolase; Experimentally verified as part of mature spore proteome PMID:19542279.
  
 
 0.932
KbaY
Putative ketose-bisphophate aldolase class II; putative tagatose-bisphosphate aldolase GatY.
  
 
 0.932
scrK
Fructokinase.
  
 
 0.919
mtlD
Mannitol-1-phosphate 5-dehydrogenase.
  
 
 0.917
fbp
Fructose-1,6-bisphosphatase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651.
     
 0.916
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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