feoB2 protein (Clostridioides difficile) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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feoB2

Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. (648 aa)

Predicted Functional Partners:

feoA4

0.941

feoA1

0.837

feoA3

0.824

leuC

0.644

feoA2

0.620

oraS

0.611

leuD

0.591

feoA

0.573

hemB

0.522

leuB

0.492

Your Current Organism:

Clostridioides difficile

NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
feoA	feoA1	CD630_14770	CD630_14780	Ferrous iron transport protein.	Ferrous iron transport protein.	0.875
feoA	feoA4	CD630_14770	CD630_32730	Ferrous iron transport protein.	Ferrous iron transport protein; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651.	0.690
feoA	feoB2	CD630_14770	CD630_32740	Ferrous iron transport protein.	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	0.573
feoA1	feoA	CD630_14780	CD630_14770	Ferrous iron transport protein.	Ferrous iron transport protein.	0.875
feoA1	feoB2	CD630_14780	CD630_32740	Ferrous iron transport protein.	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	0.837
feoA2	feoB2	CD630_15180	CD630_32740	Ferrous iron transport protein.	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	0.620
feoA3	feoB2	CD630_17451	CD630_32740	Ferrous iron transport protein.	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	0.824
feoA4	feoA	CD630_32730	CD630_14770	Ferrous iron transport protein; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651.	Ferrous iron transport protein.	0.690
feoA4	feoB2	CD630_32730	CD630_32740	Ferrous iron transport protein; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651.	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	0.941
feoB2	feoA	CD630_32740	CD630_14770	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	Ferrous iron transport protein.	0.573
feoB2	feoA1	CD630_32740	CD630_14780	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	Ferrous iron transport protein.	0.837
feoB2	feoA2	CD630_32740	CD630_15180	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	Ferrous iron transport protein.	0.620
feoB2	feoA3	CD630_32740	CD630_17451	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	Ferrous iron transport protein.	0.824
feoB2	feoA4	CD630_32740	CD630_32730	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	Ferrous iron transport protein; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651.	0.941
feoB2	hemB	CD630_32740	CD630_34190	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family.	0.522
feoB2	leuB	CD630_32740	CD630_09920	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.492
feoB2	leuC	CD630_32740	CD630_09900	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.644
feoB2	leuD	CD630_32740	CD630_09910	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.	0.591
feoB2	oraS	CD630_32740	CD630_04450	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	D-ornithine aminomutase S component.	0.611
hemB	feoB2	CD630_34190	CD630_32740	Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family.	Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.	0.522

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Network Stats

number of nodes:

6

number of edges:

9

average node degree:

3

avg. local clustering coefficient:

0.9

expected number of edges:

5

PPI enrichment p-value:

0.0711

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006508

Proteolysis

4 of 129

1.39

0.9

0.0151

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004175

Endopeptidase activity

4 of 56

1.76

1.79

0.00035

GO:0004252

Serine-type endopeptidase activity

3 of 36

1.82

1.32

0.0047

GO:0004176

ATP-dependent peptidase activity

2 of 6

2.42

1.31

0.0081

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34171185

(2021) Strain diversity of plant-associated Lactiplantibacillus plantarum.

2 of 14

2.06

1.14

0.0130

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5198

Mixed, incl. Redoxin, and Prolyl oligopeptidase family

3 of 7

2.53

2.32

0.00018

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009368

Endopeptidase Clp complex

2 of 5

2.5

1.29

0.0091

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0720

Serine protease

2 of 7

2.36

1.23

0.0110

KW-0645

Protease

3 of 67

1.55

1.03

0.0110

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00574

Clp protease

2 of 2

2.9

1.42

0.0061

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033135

ClpP, histidine active site

2 of 2

2.9

1.18

0.0147

IPR023562

Clp protease proteolytic subunit /Translocation-enhancing protein TepA

2 of 2

2.9

1.18

0.0147

IPR001907

ATP-dependent Clp protease proteolytic subunit

2 of 2

2.9

1.18

0.0147

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