STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proC1Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa)    
Predicted Functional Partners:
pflD-2
Pyruvate formate-lyase.
  
 
 0.955
prdF
Proline racemase; Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways (By similarity).
  
 
 0.933
ArcB
Putative ornithine cyclodeaminase.
  
 
 0.929
pepI
Proline iminopeptidase (Proline aminopeptidase) (PIP), peptidase S33 family; Releases the N-terminal proline from various substrates. Belongs to the peptidase S33 family.
  
 
 0.902
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
  
 
 
0.901
CAJ69509.1
Putative pyridoxal 5'-phosphate-dependent enzyme; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
 0.749
pflD
Formate acetyltransferase (Pyruvate formate-lyase).
  
  
 0.633
hisI
Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphatase]; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.606
guaA
Fragment of conserved hypothetical protein,DUF111 family; Catalyzes the synthesis of GMP from XMP.
  
  
 0.551
glnA
Glutamine synthetase.
  
  
 0.540
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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